Seroatlas · Human Serome Atlas

UBXN10

UBX domain-containing protein 10

Also known as: FLJ25429, UBX10_HUMAN, UBXD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LJ8
Gene: UBXN10
Ensembl: ENSG00000162543
Chromosome: 1
Canonical length: 280 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Involved in cilium assembly. Located in cilium and intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q96LJ8|UBXN10
     1  MATEAPVNIA PPECSTVVST AVDSLIWQPN SLNMHMIRPK SAKGRTRPSL QKSQGVEVCA
    61  HHIPSPPPAI PYELPSSQKP GACAPKSPNQ GASDEIPELQ QQVPTGASSS LNKYPVLPSI
   121  NRKNLEEEAV ETVAKKASSL QLSSIRALYQ DETGTMKTSE EDSRARACAV ERKFIVRTKK
   181  QGSSRAGNLE EPSDQEPRLL LAVRSPTGQR FVRHFRPTDD LQTIVAVAEQ KNKTSYRHCS
   241  IETMEVPRRR FSDLTKSLQE CRIPHKSVLG ISLEDGEGWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 47 nTPM
choroid plexus: 22 nTPM
testis: 13 nTPM
colon: 8.9 nTPM
cervix: 6.7 nTPM
endometrium: 5.8 nTPM

Single-cell type

respiratory ciliated cells: 209 nCPM
late spermatids: 207 nCPM
fallopian tube ciliated cells: 194 nCPM
late primary spermatocytes: 148 nCPM
early spermatids: 106 nCPM
endometrial ciliated cells: 88 nCPM

Immune cell

NK-cell: 4.1 nTPM
MAIT T-cell: 2.7 nTPM
gdT-cell: 2.6 nTPM
memory CD8 T-cell: 0.9 nTPM
myeloid DC: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM

Brain region

choroid plexus: 33 nTPM
midbrain: 13 nTPM
medulla oblongata: 12 nTPM
spinal cord: 11 nTPM
white matter: 9.7 nTPM
thalamus: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.01
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN10 as an antibody target. Whether an autoantibody or antibody against UBXN10 could matter depends on whether native UBXN10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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