Seroatlas · Human Serome Atlas

CCDC15

Coiled-coil domain-containing protein 15

Also known as: CCD15_HUMAN, FLJ13215

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P6D6
Gene: CCDC15
Ensembl: ENSG00000149548
Chromosome: 11
Canonical length: 951 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in cilium assembly and positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

951 residues, UniProt reviewed canonical sequence.

>Q0P6D6|CCDC15
     1  MLGSMARKKP RNTSRLPLAL NPLKSKDVLA VLAERNEAIV PVGAWVEPAS PGSSEIPAYT
    61  SAYLIEEELK EQLRKKQEAL KHFQKQVKYR VNQQIRLRKK QQLQKSYERA QKEGSIAMQS
   121  SATHLTSKRT SVFPNNLNVA IGSSRLPPSL MPGDGIEDEE NQNELFQQQA QALSETMKQA
   181  RHRLASFKTV IKKKGSVFPD DGRKSFLTRE EVLSRKPAST GINTGIRGEL PIKVHQGLLA
   241  AVPYQNYMEN QELDYEEPDY EESSSLVTDE KGKEDLFGRG QQDQQAIHSE DKNKPFSRVQ
   301  KVKFKNPLFV LMEEEEQKQL HFEGLQDILP EAQDYFLEAQ GDLLETQGDL TGIQSVKPDT
   361  QAVEMKVQVT EPEGQAIEPE GQPIKTETQG IMLKAQSIEL EEGSIVLKTQ DFLPTNQALL
   421  TKNQDVLLKD HCVLPKDQSI LLKYQDQDFL PRDQHVLHKD QDILPKYQDQ NFLPKDQNFL
   481  SRDQHVLPKD QDILPKYQDQ NFLPKDQNFL SRDQHVLPKD QNILPKYQGQ DFLPKDQDFL
   541  SRDQHVLPKD WNILPKCQDQ DFLPRDQGVL PKDQNILPIC QDQDFLPRDQ GYLPKDQNIL
   601  PICQDRDFLP RDLHVLSNDQ NILPKCQDQD FLPKYQKVHF KEPYSDMTDE KGREDFSLAD
   661  YQCLPPKSQD QDDIKNQQPA SFMREERVRE ELPLDYHQYV VPKIQDQDSP REQNKHIKLP
   721  SSFEKWEIAR GNTPGVPLAY DRYQSGLSTE FQAPLAFQSD VDKEEDKKER QKQYLRHRRL
   781  FMDIEREQVK EQQRQKEQKK KIEKIKKKRE QECYAAEQRI LRMNFHEDPY SGEKLSEILA
   841  QLQLQEIKGT REKQQREKEY LRYVEALRAQ IQEKMQLYNI TLPPLCCCGP DFWDAHPDTC
   901  ANNCIFYKNH RAYTRALHSF INSCDVPGGN STLRVAIHNF ASAHRRTLKN L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

testis: 9.8 nTPM
salivary gland: 3.8 nTPM
breast: 2.6 nTPM
thymus: 2.6 nTPM
bone marrow: 2 nTPM
skin: 2 nTPM

Single-cell type

early primary spermatocytes: 120 nCPM
late primary spermatocytes: 74 nCPM
erythrocyte progenitors: 70 nCPM
early spermatids: 65 nCPM
late spermatids: 62 nCPM
megakaryocyte progenitors: 39 nCPM

Immune cell

basophil: 4.1 nTPM
memory CD8 T-cell: 1.7 nTPM
T-reg: 1.7 nTPM
naive CD8 T-cell: 1.4 nTPM
naive CD4 T-cell: 1.3 nTPM
MAIT T-cell: 1.1 nTPM

Brain region

white matter: 2.8 nTPM
medulla oblongata: 2.3 nTPM
basal ganglia: 2 nTPM
spinal cord: 1.9 nTPM
thalamus: 1.9 nTPM
midbrain: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 15

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC15 as an antibody target. Whether an autoantibody or antibody against CCDC15 could matter depends on whether native CCDC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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