Seroatlas · Human Serome Atlas

POC5

Centrosomal protein POC5

Also known as: C5orf37, FLJ35779, hPOC5, MGC120442, MGC120443, MGC120444, POC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA72
Gene: POC5
Ensembl: ENSG00000152359
Chromosome: 5
Canonical length: 575 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in centriole elongation and negative regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q8NA72|POC5
     1  MSSDEEKYSL PVVQNDSSRG SSVSSNLQEE YEELLHYAIV TPNIEPCASQ SSHPKGELVP
    61  DVRISTIHDI LHSQGNNSEV RETAIEVGKG CDFHISSHSK TDESSPVLSP RKPSHPVMDF
   121  FSSHLLADSS SPATNSSHTD AHEILVSDFL VSDENLQKME NVLDLWSSGL KTNIISELSK
   181  WRLNFIDWHR MEMRKEKEKH AAHLKQLCNQ INELKELQKT FEISIGRKDE VISSLSHAIG
   241  KQKEKIELMR TFFHWRIGHV RARQDVYEGK LADQYYQRTL LKKVWKVWRS VVQKQWKDVV
   301  ERACQARAEE VCIQISNDYE AKVAMLSGAL ENAKAEIQRM QHEKEHFEDS MKKAFMRGVC
   361  ALNLEAMTIF QNRNDAGIDS TNNKKEEYGP GVQGKEHSAH LDPSAPPMPL PVTSPLLPSP
   421  PAAVGGASAT AVPSAASMTS TRAASASSVH VPVSALGAGS AATAASEEMY VPRVVTSAQQ
   481  KAGRTITARI TGRCDFASKN RISSSLAIMG VSPPMSSVVV EKHHPVTVQT IPQATAAKYP
   541  RTIHPESSTS ASRSLGTRSA HTQSLTSVHS IKVVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

retina: 27 nTPM
testis: 19 nTPM
thymus: 13 nTPM
lymph node: 11 nTPM
tonsil: 10 nTPM
bone marrow: 9.6 nTPM

Single-cell type

late primary spermatocytes: 152 nCPM
rod photoreceptor cells: 100 nCPM
early spermatids: 75 nCPM
late spermatids: 64 nCPM
oocytes: 60 nCPM
microglia: 36 nCPM

Immune cell

eosinophil: 23 nTPM
T-reg: 22 nTPM
NK-cell: 19 nTPM
naive B-cell: 18 nTPM
plasmacytoid DC: 17 nTPM
memory CD8 T-cell: 16 nTPM

Brain region

white matter: 20 nTPM
basal ganglia: 14 nTPM
medulla oblongata: 13 nTPM
pons: 13 nTPM
cerebellum: 13 nTPM
cerebral cortex: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POC5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 399 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Scoliosis, isolated, susceptibility to, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal protein POC5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POC5 as an antibody target. Whether an autoantibody or antibody against POC5 could matter depends on whether native POC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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