Seroatlas · Human Serome Atlas

SLC22A1

Solute carrier family 22 member 1

Also known as: 1-Oct, S22A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15245
Gene
SLC22A1
Ensembl
ENSG00000175003
Chromosome
6
Canonical length
554 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>O15245|SLC22A1
     1  MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ
    61  RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP
   121  CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL
   181  GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY
   241  QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK
   301  IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL
   361  YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM
   421  IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT
   481  PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN
   541  TIYLKVQTSE PSGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
596 nTPM

Expression across tissuesHPA

Tissue

  • liver: 596 nTPM
  • spleen: 1.4 nTPM
  • skeletal muscle: 0.9 nTPM
  • kidney: 0.8 nTPM
  • thyroid gland: 0.7 nTPM
  • gallbladder: 0.6 nTPM

Single-cell type

  • hepatocytes: 1,218 nCPM
  • neutrophils: 118 nCPM
  • cholangiocytes: 65 nCPM
  • endometrial secretory cells: 17 nCPM
  • endometrial luminal cells: 16 nCPM
  • epididymal clear cells: 14 nCPM

Immune cell

  • neutrophil: 3.5 nTPM
  • gdT-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • cerebral cortex: 3.3 nTPM
  • hippocampal formation: 2.4 nTPM
  • amygdala: 1.9 nTPM
  • pons: 1.9 nTPM
  • choroid plexus: 1.8 nTPM
  • basal ganglia: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC22A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A1 as an antibody target. Whether an autoantibody or antibody against SLC22A1 could matter depends on whether native SLC22A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A1 is annotated at the cell surface, where native SLC22A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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