Seroatlas · Human Serome Atlas

MLLT6

Protein AF-17

Also known as: AF17, AF17_HUMAN, FLJ23480

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55198
Gene: MLLT6
Ensembl: ENSG00000275023
Chromosome: 17
Canonical length: 1093 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables histone binding activity and nucleosome binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including renal potassium excretion; renal sodium excretion; and renal water absorption. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>P55198|MLLT6
     1  MKEMVGGCCV CSDERGWAEN PLVYCDGHAC SVAVHQACYG IVQVPTGPWF CRKCESQERA
    61  ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV LTMEPIVLQY VPHDRFNKTC
   121  YICEEQGRES KAASGACMTC NRHGCRQAFH VTCAQMAGLL CEEEVLEVDN VKYCGYCKYH
   181  FSKMKTSRHS SGGGGGGAGG GGGSMGGGGS GFISGRRSRS ASPSTQQEKH PTHHERGQKK
   241  SRKDKERLKQ KHKKRPESPP SILTPPVVPT ADKVSSSASS SSHHEASTQE TSESSRESKG
   301  KKSSSHSLSH KGKKLSSGKG VSSFTSASSS SSSSSSSSGG PFQPAVSSLQ SSPDFSAFPK
   361  LEQPEEDKYS KPTAPAPSAP PSPSAPEPPK ADLFEQKVVF SGFGPIMRFS TTTSSSGRAR
   421  APSPGDYKSP HVTGSGASAG THKRMPALSA TPVPADETPE TGLKEKKHKA SKRSRHGPGR
   481  PKGSRNKEGT GGPAAPSLPS AQLAGFTATA ASPFSGGSLV SSGLGGLSSR TFGPSGSLPS
   541  LSLESPLLGA GIYTSNKDPI SHSGGMLRAV CSTPLSSSLL GPPGTSALPR LSRSPFTSTL
   601  PSSSASISTT QVFSLAGSTF SLPSTHIFGT PMGAVNPLLS QAESSHTEPD LEDCSFRCRG
   661  TSPQESLSSM SPISSLPALF DQTASAPCGG GQLDPAAPGT TNMEQLLEKQ GDGEAGVNIV
   721  EMLKALHALQ KENQRLQEQI LSLTAKKERL QILNVQLSVP FPALPAALPA ANGPVPGPYG
   781  LPPQAGSSDS LSTSKSPPGK SSLGLDNSLS TSSEDPHSGC PSRSSSSLSF HSTPPPLPLL
   841  QQSPATLPLA LPGAPAPLPP QPQNGLGRAP GAAGLGAMPM AEGLLGGLAG SGGLPLNGLL
   901  GGLNGAAAPN PASLSQAGGA PTLQLPGCLN SLTEQQRHLL QQQEQQLQQL QQLLASPQLT
   961  PEHQTVVYQM IQQIQQKREL QRLQMAGGSQ LPMASLLAGS STPLLSAGTP GLLPTASAPP
  1021  LLPAGALVAP SLGNNTSLMA AAAAAAAVAA AGGPPVLTAQ TNPFLSLSGA EGSGGGPKGG
  1081  TADKGASANQ EKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLLT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

ovary: 76 nTPM
skeletal muscle: 75 nTPM
pituitary gland: 74 nTPM
cerebellum: 69 nTPM
thyroid gland: 66 nTPM
spleen: 62 nTPM

Single-cell type

renal collecting duct intercalated cells: 106 nCPM
distal convoluted tubule cells: 102 nCPM
loop of henle epithelial cells: 101 nCPM
microglia: 81 nCPM
renal connecting tubule cells: 74 nCPM
renal collecting duct principal cells: 71 nCPM

Immune cell

basophil: 0.4 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

cerebellum: 38 nTPM
cerebral cortex: 38 nTPM
amygdala: 29 nTPM
white matter: 28 nTPM
medulla oblongata: 28 nTPM
hypothalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 2.1
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLLT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLLT6 as an antibody target. Whether an autoantibody or antibody against MLLT6 could matter depends on whether native MLLT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLLT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLLT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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