Seroatlas · Human Serome Atlas

CCNY

Cyclin-Y

Also known as: C10orf9, CBCP1, CCNY_HUMAN, CFP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND76
Gene: CCNY
Ensembl: ENSG00000108100
Chromosome: 10
Canonical length: 341 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8ND76|CCNY
     1  MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI DDLNMEFNPS
    61  DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS CSTIFLDDST VSQPNLKYTI
   121  KCVALAIYYH IKNRDPDGRM LLDIFDENLH PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS
   181  AAQLTAECAI VTLVYLERLL TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI
   241  LKDITVEDMN ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
   301  KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

testis: 74 nTPM
cerebral cortex: 38 nTPM
amygdala: 37 nTPM
placenta: 36 nTPM
basal ganglia: 35 nTPM
bone marrow: 34 nTPM

Single-cell type

late spermatids: 6,772 nCPM
early spermatids: 1,191 nCPM
oligodendrocytes: 515 nCPM
neutrophils: 485 nCPM
vascular endothelial cells: 403 nCPM
microglia: 386 nCPM

Immune cell

neutrophil: 26 nTPM
classical monocyte: 23 nTPM
myeloid DC: 7.8 nTPM
total PBMC: 7.6 nTPM
intermediate monocyte: 6.5 nTPM
eosinophil: 5.2 nTPM

Brain region

hippocampal formation: 56 nTPM
cerebral cortex: 56 nTPM
basal ganglia: 55 nTPM
thalamus: 54 nTPM
amygdala: 52 nTPM
midbrain: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.81
gnomAD missense Z: 2.04
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNY as an antibody target. Whether an autoantibody or antibody against CCNY could matter depends on whether native CCNY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNY is annotated at the cell surface, where native CCNY is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCNY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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