Seroatlas · Human Serome Atlas

CCNYL1

Cyclin-Y-like protein 1

Also known as: CCYL1_HUMAN, FLJ40432

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7R7
Gene: CCNYL1
Ensembl: ENSG00000163249
Chromosome: 2
Canonical length: 359 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q8N7R7|CCNYL1
     1  MGNTLTCCVS PNASPKLGRR AGSAELYCAS DIYEAVSGDA VAVAPAVVEP AELDFGEGEG
    61  HHLQHISDRE MPEDLALESN PSDHPRASTI FLSKSQTDVR EKRKSNHLNH VSPGQLTKKY
   121  SSCSTIFLDD STVSQPNLRT TVKCVTLAIY YHIKNRDANR SLDIFDERSH PLTREKVPEE
   181  YFKHDPEHKF IYRFVRTLFS AAQLTAECAI VTLVYLERLL TYAEIDICPT NWKRIVLGAI
   241  LLASKVWDDQ AVWNVDYCQI LKDITVEDMN EMERHFLELL QFNINVPASV YAKYYFDLRS
   301  LADDNNLNFL FAPLSKERAQ NLEAISRLCE DKDLCRAAMR RSFSADNFIG IQRSKAILS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNYL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

esophagus: 17 nTPM
testis: 15 nTPM
colon: 14 nTPM
placenta: 13 nTPM
pancreas: 13 nTPM
rectum: 13 nTPM

Single-cell type

mesothelial cells: 265 nCPM
epicardial cells: 200 nCPM
colonocytes: 189 nCPM
ocular epithelial cells: 182 nCPM
esophageal apical cells: 171 nCPM
cardiomyocytes: 135 nCPM

Immune cell

neutrophil: 1.3 nTPM
classical monocyte: 1.1 nTPM
naive B-cell: 1 nTPM
naive CD8 T-cell: 0.8 nTPM
basophil: 0.6 nTPM
intermediate monocyte: 0.6 nTPM

Brain region

white matter: 19 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.59
gnomAD missense Z: 1.62
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNYL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDK16

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNYL1 as an antibody target. Whether an autoantibody or antibody against CCNYL1 could matter depends on whether native CCNYL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNYL1 is annotated at the cell surface, where native CCNYL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCNYL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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