Seroatlas · Human Serome Atlas

SYF2

Pre-mRNA-splicing factor SYF2

Also known as: CBPIN, DKFZp564O2082, fSAP29, NTC31, p29, SYF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95926
Gene: SYF2
Ensembl: ENSG00000117614
Chromosome: 1
Canonical length: 243 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>O95926|SYF2
     1  MAAIAASEVL VDSAEEGSLA AAAELAAQKR EQRLRKFREL HLMRNEARKL NHQEVVEEDK
    61  RLKLPANWEA KKARLEWELK EEEKKKECAA RGEDYEKVKL LEISAEDAER WERKKKRKNP
   121  DLGFSDYAAA QLRQYHRLTK QIKPDMETYE RLREKHGEEF FPTSNSLLHG THVPSTEEID
   181  RMVIDLEKQI EKRDKYSRRR PYNDDADIDY INERNAKFNK KAERFYGKYT AEIKQNLERG
   241  TAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 139 nTPM
ovary: 98 nTPM
blood vessel: 89 nTPM
skeletal muscle: 77 nTPM
thymus: 72 nTPM
tonsil: 72 nTPM

Single-cell type

syncytiotrophoblasts: 351 nCPM
esophageal apical cells: 310 nCPM
neutrophils: 299 nCPM
enterocytes: 294 nCPM
ovarian stromal cells: 289 nCPM
epididymal efferent duct absorptive cells: 246 nCPM

Immune cell

neutrophil: 339 nTPM
eosinophil: 224 nTPM
basophil: 186 nTPM
memory B-cell: 141 nTPM
T-reg: 130 nTPM
naive B-cell: 126 nTPM

Brain region

hypothalamus: 27 nTPM
white matter: 25 nTPM
medulla oblongata: 23 nTPM
cerebellum: 23 nTPM
spinal cord: 21 nTPM
choroid plexus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.01
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.99
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

mRNA splicing factor SYF2
SYF2 splicing factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYF2 as an antibody target. Whether an autoantibody or antibody against SYF2 could matter depends on whether native SYF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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