Seroatlas · Human Serome Atlas

ZNF627

Zinc finger protein 627

Also known as: FLJ90365, ZN627_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L945
Gene
ZNF627
Ensembl
ENSG00000198551
Chromosome
19
Canonical length
461 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q7L945|ZNF627
     1  MDSVAFEDVA VNFTLEEWAL LDPSQKNLYR DVMRETFRNL ASVGKQWEDQ NIEDPFKIPR
    61  RNISHIPERL CESKEGGQGE ETFSQIPDGI LNKKTPGVKP CESSVCGEVG MGPSSLNRHI
   121  RDHTGREPNE YQEYGKKSYT RNQCGRALSY HRSFPVRERT HPGGKPYDCK ECGETFISLV
   181  SIRRHMLTHR GGVPYKCKVC GKAFDYPSLF RIHERSHTGE KPYECKQCGK AFSCSSYIRI
   241  HERTHTGDKP YECKQCGKAF SCSKYIRIHE RTHTGEKPYE CKQCGKAFRC ASSVRSHERT
   301  HTGEKLFECK ECGKALTCLA SVRRHMIKHT GNGPYKCKVC GKAFDFPSSF RIHERTHTGE
   361  KPYDCKQCGK AFSCSSSFRK HERIHTGEKP YKCTKCGKAF SRSSYFRIHE RTHTGEKPYE
   421  CKQCGKAFSR STYFRVHEKI HTGEKPYENP NPNASVVPVL S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF627 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 13 nTPM
  • thyroid gland: 12 nTPM
  • fallopian tube: 12 nTPM
  • breast: 10 nTPM
  • endometrium: 9.9 nTPM
  • kidney: 9 nTPM

Single-cell type

  • rod photoreceptor cells: 50 nCPM
  • proximal tubule cells: 44 nCPM
  • loop of henle epithelial cells: 40 nCPM
  • thymocytes: 39 nCPM
  • respiratory ciliated cells: 37 nCPM
  • distal convoluted tubule cells: 36 nCPM

Immune cell

  • basophil: 14 nTPM
  • memory B-cell: 9.1 nTPM
  • eosinophil: 7.4 nTPM
  • naive CD4 T-cell: 7.4 nTPM
  • NK-cell: 7.3 nTPM
  • myeloid DC: 7.2 nTPM

Brain region

  • white matter: 13 nTPM
  • cerebellum: 13 nTPM
  • medulla oblongata: 10 nTPM
  • spinal cord: 10 nTPM
  • hypothalamus: 10 nTPM
  • midbrain: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0.33
gnomAD missense Z
0.73
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF627 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF627 as an antibody target. Whether an autoantibody or antibody against ZNF627 could matter depends on whether native ZNF627 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF627 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF627 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF627. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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