Seroatlas · Human Serome Atlas

EURL

Protein EURL homolog

Also known as: C21orf14, C21orf38, C21orf91, CSSG1, EURL_HUMAN, YG81

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYK6
Gene: EURL
Ensembl: ENSG00000154642
Chromosome: 21
Canonical length: 297 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Predicted to be involved in cerebral cortex neuron differentiation and positive regulation of dendritic spine development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q9NYK6|EURL
     1  MNEEEQFVNI DLNDDNICSV CKLGTDKETL SFCHICFELN IEGVPKSDLL HTKSLRGHKD
    61  CFEKYHLIAN QGCPRSKLSK STYEEVKTIL SKKINWIVQY AQNKDLDSDS ECSKNPQHHL
   121  FNFRHKPEEK LLPQFDSQVP KYSAKWIDGS AGGISNCTQR ILEQRENTDF GLSMLQDSGA
   181  TLCRNSVLWP HSHNQAQKKE ETISSPEANV QTQHPHYSRE ELNSMTLGEV EQLNAKLLQQ
   241  IQEVFEELTH QVQEKDSLAS QLHVRHVAIE QLLKNCSKLP CLQVGRTGMK SHLPINN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EURL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
spinal cord: 22 nTPM
skin: 18 nTPM
thymus: 18 nTPM
lymph node: 14 nTPM
placenta: 13 nTPM

Single-cell type

early spermatids: 492 nCPM
oligodendrocytes: 114 nCPM
late spermatids: 112 nCPM
late primary spermatocytes: 105 nCPM
megakaryocyte progenitors: 87 nCPM
syncytiotrophoblasts: 83 nCPM

Immune cell

basophil: 111 nTPM
eosinophil: 57 nTPM
T-reg: 37 nTPM
MAIT T-cell: 30 nTPM
neutrophil: 25 nTPM
memory CD8 T-cell: 23 nTPM

Brain region

white matter: 121 nTPM
medulla oblongata: 57 nTPM
basal ganglia: 56 nTPM
cerebellum: 48 nTPM
midbrain: 46 nTPM
spinal cord: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

EURL protein
EURL protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EURL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CCDC85B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EURL as an antibody target. Whether an autoantibody or antibody against EURL could matter depends on whether native EURL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EURL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EURL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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