Seroatlas · Human Serome Atlas

ANKRD26

Ankyrin repeat domain-containing protein 26

Also known as: ANR26_HUMAN, KIAA1074, THC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPS8
Gene: ANKRD26
Ensembl: ENSG00000107890
Chromosome: 10
Canonical length: 1710 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

1710 residues, UniProt reviewed canonical sequence.

>Q9UPS8|ANKRD26
     1  MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI HKAASAGNVA
    61  KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV DRKCQLNVCD NENRTALMKA
   121  VQCQEEKCAT ILLEHGADPN LADVHGNTAL HYAVYNEDIS VATKLLLYDA NIEAKNKDDL
   181  TPLLLAVSGK KQQMVEFLIK KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES
   241  SEDSLSRLSG KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR
   301  TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK SLANPGLMKE
   361  EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN RSDMMSALGL GQEEDIESPW
   421  DSESISENFP QKYVDPLAGA ADGKEKNIGN EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV
   481  GMPVAHMESP ERYLHLKPTI EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE
   541  NNQPQVEEER KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN
   601  KEYASSGPAL QMKEVKSTEK EKRTSKESVN SPVFGKASLL TGGLLQVDDD SSLSEIDEDE
   661  GRPTKKTSNE KNKVKNQIQS MDDVDDLTQS SETASEDCEL PHSSYKNFML LIEQLGMECK
   721  DSVSLLKIQD AALSCERLLE LKKNHCELLT VKIKKMEDKV NVLQRELSET KEIKSQLEHQ
   781  KVEWERELCS LRFSLNQEEE KRRNADTLYE KIREQLRRKE EQYRKEVEVK QQLELSLQTL
   841  EMELRTVKSN LNQVVQERND AQRQLSREQN ARMLQDGILT NHLSKQKEIE MAQKKMNSEN
   901  SHSHEEEKDL SHKNSMLQEE IAMLRLEIDT IKNQNQEKEK KCFEDLKIVK EKNEDLQKTI
   961  KQNEETLTQT ISQYNGRLSV LTAENAMLNS KLENEKQSKE RLEAEVESYH SRLAAAIHDR
  1021  DQSETSKREL ELAFQRARDE CSRLQDKMNF DVSNLKDNNE ILSQQLFKTE SKLNSLEIEF
  1081  HHTRDALREK TLGLERVQKD LSQTQCQMKE MEQKYQNEQV KVNKYIGKQE SVEERLSQLQ
  1141  SENMLLRQQL DDAHNKADNK EKTVINIQDQ FHAIVQKLQA ESEKQSLLLE ERNKELISEC
  1201  NHLKERQYQY ENEKAEREVV VRQLQQELAD TLKKQSMSEA SLEVTSRYRI NLEDETQDLK
  1261  KKLGQIRNQL QEAQDRHTEA VRCAEKMQDH KQKLEKDNAK LKVTVKKQMD KIEELQKNLL
  1321  NANLSEDEKE QLKKLMELKQ SLECNLDQEM KKNVELEREI TGFKNLLKMT RKKLNEYENG
  1381  EFSFHGDLKT SQFEMDIQIN KLKHKIDDLT AELETAGSKC LHLDTKNQIL QEELLSMKTV
  1441  QKKCEKLQKN KKKLEQEVIN LRSHIERNMV ELGQVKQYKQ EIEERARQEI AEKLKEVNLF
  1501  LQAQAASQEN LEQFRENNFA SMKSQMELRI KDLESELSKI KTSQEDFNKT ELEKYKQLYL
  1561  EELKVRKSLS SKLTKTNERL AEVNTKLLVE KQQSRSLFTT LTTRPVMEPP CVGNLNNSLD
  1621  LNRKLIPREN LVISTSNPRA SNNSMENYLS KMQQELEKNI TRELKEAAAE LESGSIASPL
  1681  GSTDESNLNQ DLVWKASREY VQVLKKNYMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

retina: 9.3 nTPM
tongue: 7 nTPM
skeletal muscle: 6.3 nTPM
cerebellum: 4.7 nTPM
choroid plexus: 4.7 nTPM
basal ganglia: 4.3 nTPM

Single-cell type

ependymal cells: 488 nCPM
thyrotrophs: 276 nCPM
choroid plexus epithelial cells: 273 nCPM
somatotrophs: 268 nCPM
lactotrophs: 262 nCPM
myonuclei: 256 nCPM

Immune cell

plasmacytoid DC: 2.1 nTPM
naive CD4 T-cell: 1.6 nTPM
NK-cell: 1.6 nTPM
basophil: 1.1 nTPM
memory B-cell: 1 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

cerebral cortex: 23 nTPM
cerebellum: 18 nTPM
white matter: 18 nTPM
choroid plexus: 17 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANKRD26.

Disease | AllUniProt

Conditions ANKRD26 is implicated in, by any mechanism.

Thrombocytopenia 2 (THC2) MIM:188000

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 2,978 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Thrombocytopenia 2
Thrombocytopenia
Hereditary cancer-predisposing syndrome
ANKRD26-related disorder
Inherited bleeding disorder, platelet-type

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of fat cell differentiation

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD26 as an antibody target. Whether an autoantibody or antibody against ANKRD26 could matter depends on whether native ANKRD26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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