Seroatlas · Human Serome Atlas

TRAPPC14

Trafficking protein particle complex subunit 14

Also known as: C7orf43, FLJ10925, MAP11, TPC14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVR3
Gene: TRAPPC14
Ensembl: ENSG00000146826
Chromosome: 7
Canonical length: 580 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Centriolar satellite

OverviewNCBI Gene

Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly 25. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>Q8WVR3|TRAPPC14
     1  MESQCDYSMY FPAVPLPPRA ELAGDPGRYR ALPRRNHLYL GETVRFLLVL RCRGGAGSGT
    61  GGGPGLGSRG AWAELATALA ALASVSAGGG MPGGGGAGDQ DSEPPGGGDP GGGGLFRGCS
   121  PLLTHGPGPA TSGGATTLPV EEPIVSTDEV IFPLTVSLDR LPPGTPKAKI VVTVWKREIE
   181  APEVRDQGYL RLLQTRSPGE TFRGEQSAFK AQVSTLLTLL PPPVLRCRQF TVAGKHLTVL
   241  KVLNSSSQEE ISIWDIRILP NFNASYLPVM PDGSVLLVDN VCHQSGEVSM GSFCRLPGTS
   301  GCFPCPLNAL EEHNFLFQLR GGEQPPPGAK EGLEVPLIAV VQWSTPKLPF TQSIYTHYRL
   361  PSVRLDRPCF VMTASCKSPV RTYERFTVTY TLLNNLQDFL AVRLVWTPEH AQAGKQLCEE
   421  ERRAMQAALD SVVCHTPLNN LGFSRKGSAL TFSVAFQALR TGLFELSQHM KLKLQFTASV
   481  SHPPPEARPL SRKSSPSSPA VRDLVERHQA SLGRSQSFSH QQPSRSHLMR SGSVMERRAI
   541  TPPVASPVGR PLYLPPDKAV LSLDKIAKRE CKVLVVEPVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAPPC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spleen: 31 nTPM
cerebellum: 29 nTPM
testis: 29 nTPM
skin: 24 nTPM
small intestine: 21 nTPM
lymph node: 19 nTPM

Single-cell type

syncytiotrophoblasts: 20 nCPM
colonocytes: 19 nCPM
neutrophils: 19 nCPM
esophageal apical cells: 14 nCPM
microglia: 14 nCPM
late primary spermatocytes: 13 nCPM

Immune cell

neutrophil: 1.9 nTPM
eosinophil: 1.4 nTPM
memory CD4 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM
basophil: 0.6 nTPM
gdT-cell: 0.6 nTPM

Brain region

pons: 27 nTPM
hypothalamus: 27 nTPM
thalamus: 26 nTPM
medulla oblongata: 26 nTPM
midbrain: 26 nTPM
cerebral cortex: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAPPC14.

Disease | AllUniProt

Conditions TRAPPC14 is implicated in, by any mechanism.

Microcephaly 25, primary, autosomal recessive (MCPH25) MIM:618351

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 26 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly 25, primary, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.18
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

alpha-tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trafficking protein particle complex subunit 14
TRAPP14, C-terminal
TRAPP14, N-terminal
TRAPP14 N-terminal
TRAPP14 C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAPPC14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAPPC14 as an antibody target. Whether an autoantibody or antibody against TRAPPC14 could matter depends on whether native TRAPPC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAPPC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAPPC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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