Seroatlas · Human Serome Atlas

TMPRSS11B

Transmembrane protease serine 11B

Also known as: HATL5, TM11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86T26
Gene: TMPRSS11B
Ensembl: ENSG00000185873
Chromosome: 4
Canonical length: 416 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q86T26|TMPRSS11B
     1  MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND
    61  NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLKFKFP
   121  PAEGVSMRTK IKAKLHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII
   181  TGNKIVNGKS SLEGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF
   241  GIVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE
   301  NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML CAGFMSGEAD
   361  ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 383 nTPM

Expression across tissuesHPA

Tissue

esophagus: 383 nTPM
vagina: 114 nTPM
cervix: 106 nTPM
tonsil: 77 nTPM
salivary gland: 51 nTPM
choroid plexus: 0.4 nTPM

Single-cell type

esophageal apical cells: 17,629 nCPM
suprabasal keratinocytes: 338 nCPM
esophageal suprabasal cells: 75 nCPM
late spermatids: 28 nCPM
early spermatids: 11 nCPM
esophageal basal cells: 10 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 2.3 nTPM
cerebral cortex: 1.8 nTPM
medulla oblongata: 1.8 nTPM
pons: 1.7 nTPM
midbrain: 1.5 nTPM
spinal cord: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMPRSS11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS11B as an antibody target. Whether an autoantibody or antibody against TMPRSS11B could matter depends on whether native TMPRSS11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS11B is annotated at the cell surface, where native TMPRSS11B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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