Seroatlas · Human Serome Atlas

SYS1

Protein SYS1 homolog

Also known as: C20orf169, dJ453C12.4, SYS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2H4
Gene: SYS1
Ensembl: ENSG00000204070
Chromosome: 20
Canonical length: 156 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>Q8N2H4|SYS1
     1  MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDGL VRSSPSLDQM FDAEILGFST
    61  PPGRLSMMSF ILNALTCALG LLYFIRRGKQ CLDFTVTVHF FHLLGCWFYS SRFPSALTWW
   121  LVQAVCIALM AVIGEYLCMR TELKEIPLNS APKSNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 73 nTPM
fallopian tube: 31 nTPM
thyroid gland: 28 nTPM
lymph node: 25 nTPM
salivary gland: 25 nTPM
bone marrow: 24 nTPM

Single-cell type

epicardial cells: 32 nCPM
ependymal cells: 16 nCPM
choroid plexus epithelial cells: 16 nCPM
oligodendrocytes: 14 nCPM
other brain neurons: 11 nCPM
bergmann glia: 10 nCPM

Immune cell

plasmacytoid DC: 104 nTPM
basophil: 52 nTPM
T-reg: 38 nTPM
eosinophil: 38 nTPM
MAIT T-cell: 36 nTPM
naive CD4 T-cell: 35 nTPM

Brain region

choroid plexus: 92 nTPM
white matter: 37 nTPM
thalamus: 36 nTPM
hypothalamus: 36 nTPM
basal ganglia: 35 nTPM
midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.07
gnomAD missense Z: 0.66
DepMap mean gene effect: -1.13
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integral membrane protein SYS1-related
Integral membrane protein SYS1
Integral membrane protein S linking to the trans Golgi network

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYS1 as an antibody target. Whether an autoantibody or antibody against SYS1 could matter depends on whether native SYS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...