DNAAF9

Protein identityUniProt · HPA

UniProt accession

Q5TEA3

Gene

DNAAF9

Ensembl

ENSG00000088854

Chromosome

20

Canonical length

1177 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes an uncharacterized protein with a C-terminal coiled-coil region. The gene is located on chromosome 20p13 in a 1.8 Mb region linked to a spinocerebellar ataxia phenotype, but this gene does not appear to be a disease candidate. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

1177 residues, UniProt reviewed canonical sequence.

>Q5TEA3|DNAAF9
     1  MDVYPPRRQG LPRARSPGGS SRGSPSVSCS RLRQVQSILT QSSKSRPDGI LCILGIDSRY
    61  NEGCRELANY LLFGLYNQNT SDFEKTGFSE EVLDDVIILI KSDSVHLYCN PVNFRYLLPY
   121  VAHWRNLHFH CMTENEYEDE EAAEEFKITS FVDMVRDCSR IGIPYSSQGH LQIFDMFVVE
   181  KWPIVQAFAL EGIGGDGFFT MKYELQDVSL NLWNVYSKMD PMSLESLLSD DLVAFEHQWT
   241  SFFANFDTEI PFLLELSESQ AGEPFRSYFS HGMISSHITE NSPNRQPFVL FGNHSTRENL
   301  NAGNFNFPSE GHLVRSTGPG GSFAKHMVAQ CVSPKGPLAC SRTYFFGATH VPYLGGDSKL
   361  PKKTEQIRLL SQIYAAVIEA VLAGIACYAK TSSLTKAKEV AEQTLGSGLD SFELIPFKAA
   421  LRSKMTFHIH AVNNQGRIVP LDSEDSLSFV KTACMAVYDI PDLLGGNGCL GSVVFSESFL
   481  TSQILVKEKD GTVTTETSSV VLTAAVPRFC SWLVEDNEVK LSEKTQQAVR GDESFLGTYL
   541  TGGEGAYLYS SNLQSWPEEG NVHFFSSGLL FSHCRHRSII ISKDHMNSIS FYDGDSTSTV
   601  AALLIDFKSS LLPHLPVHFH GSSNFLMIAL FPKSKIYQAF YSEVFSLWKQ QDNSGISLKV
   661  IQEDGLSVEQ KRLHSSAQKL FSALSQPAGE KRSSLKLLSA KLPELDWFLQ HFAISSISQE
   721  PVMRTHLPVL LQQAEINTTH RIESDKVIIS IVTGLPGCHA SELCAFLVTL HKECGRWMVY
   781  RQIMDSSECF HAAHFQRYLS SALEAQQNRS ARQSAYIRKK TRLLVVLQGY TDVIDVVQAL
   841  QTHPDSNVKA SFTIGAITAC VEPMSCYMEH RFLFPKCLDQ CSQGLVSNVV FTSHTTEQRH
   901  PLLVQLQSLI RAANPAAAFI LAENGIVTRN EDIELILSEN SFSSPEMLRS RYLMYPGWYE
   961  GKLNAGSVYP LMVQICVWFG RPLEKTRFVA KCKAIQSSIK PSPFSGNIYH ILGKVKFSDS
  1021  ERTMEVCYNT LANSLSIMPV LEGPTPPPDS KSVSQDSSGQ QECYLVFIGC SLKEDSIKDW
  1081  LRQSAKQKPQ RKALKTRGML TQQEIRSIHV KRHLEPLPAG YFYNGTQFVN FFGDKTDFHP
  1141  LMDQFMNDYV EEANREIEKY NQELEQQEYH DLFELKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAAF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

30 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAAF9.

Disease | ImmuneIEDB

Conditions an epitope on DNAAF9 was assayed in.

• viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.6

gnomAD pLI

0

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

• Dynein axonemal assembly factor 9 DNAAF9
• DAAF9, CobW C-like domain
• DAAF9, N-terminal domain
• DAAF9, domain 2
• DAAF9, PH domain
• DAAF9, pita-bread-like domain
• Dynein axonemal assembly factor 9 N-terminal domain
• DAAF9 CobW_C-like domain
• DAAF9 Pita bread like domain
• DAAF9 domain
• DAAF9 PH domain

InteractionsUniProt · HPA

Protein binding partners of DNAAF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARL3
• DYNLT2