Seroatlas · Human Serome Atlas

CFAP36

Cilia- and flagella-associated protein 36

Also known as: BARTL1, CCDC104, CFA36_HUMAN, MGC15407

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G28
Gene: CFAP36
Ensembl: ENSG00000163001
Chromosome: 2
Canonical length: 342 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies

OverviewNCBI Gene

Located in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q96G28|CFAP36
     1  MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVF DDEEESKLTY TEIHQEYKEL
    61  VEKLLEGYLK EIGINEDQFQ EACTSPLAKT HTSQAILQPV LAAEDFTIFK AMMVQKNIEM
   121  QLQAIRIIQE RNGVLPDCLT DGSDVVSDLE HEEMKILREV LRKSKEEYDQ EEERKRKKQL
   181  SEAKTEEPTV HSSEAAIMNN SQGDGEHFAH PPSEVKMHFA NQSIEPLGRK VERSETSSLP
   241  QKDLKIPGLE HASIEGPIAN LSVLGTEELR QREHYLKQKR DKLMSMRKDM RTKQIQNMEQ
   301  KGKPTGEVEE MTEKPEMTAE EKQTLLKRRL LAEKLKEEVI NK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 179 nTPM
testis: 136 nTPM
retina: 115 nTPM
pituitary gland: 114 nTPM
cerebral cortex: 111 nTPM
basal ganglia: 102 nTPM

Single-cell type

early spermatids: 1,353 nCPM
late primary spermatocytes: 1,182 nCPM
late spermatids: 294 nCPM
respiratory ciliated cells: 289 nCPM
fallopian tube ciliated cells: 237 nCPM
endometrial ciliated cells: 186 nCPM

Immune cell

memory CD4 T-cell: 51 nTPM
naive CD4 T-cell: 41 nTPM
MAIT T-cell: 35 nTPM
T-reg: 31 nTPM
memory CD8 T-cell: 30 nTPM
naive CD8 T-cell: 26 nTPM

Brain region

choroid plexus: 90 nTPM
hypothalamus: 80 nTPM
cerebral cortex: 80 nTPM
basal ganglia: 70 nTPM
pons: 66 nTPM
midbrain: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

BART domain
BART domain superfamily
The ARF-like 2 binding protein BART
Cilia- and flagella-associated protein 36

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP36 as an antibody target. Whether an autoantibody or antibody against CFAP36 could matter depends on whether native CFAP36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...