TAX1BP3

Protein identityUniProt · HPA

UniProt accession

O14907

Gene

TAX1BP3

Ensembl

ENSG00000213977

Chromosome

17

Canonical length

124 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli fibrillar center,Vesicles,Actin filaments

OverviewNCBI Gene

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>O14907|TAX1BP3
     1  MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV
    61  SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ
   121  SMLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAX1BP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

271 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.49

gnomAD pLI

0.01

gnomAD missense Z

0.9

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell population proliferation
• negative regulation of protein localization to cell surface
• negative regulation of Wnt signaling pathway
• regulation of Cdc42 protein signal transduction
• Rho protein signal transduction
• Wnt signaling pathway

Molecular functions

• beta-catenin binding

Cellular components

• actin cytoskeleton
• cytoplasm
• cytosol
• extracellular exosome
• fibrillar center
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• PDZ superfamily
• Synaptic Scaffolding LAP/MAGUK Families
• PDZ domain
• Tax1-binding protein 3

KeywordsUniProt

• Acetylation
• Cell membrane
• Cytoplasm
• Membrane
• Nucleus
• Phosphoprotein
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of TAX1BP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADGRB2
• CTNNB1
• ARHGEF16
• KCNJ4