Seroatlas · Human Serome Atlas

NYAP2

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Also known as: KIAA1486, NYAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P242
Gene
NYAP2
Ensembl
ENSG00000144460
Chromosome
2
Canonical length
653 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>Q9P242|NYAP2
     1  MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR NETNLAYLKE
    61  KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP APQDRLPHPC SSGFSVRSQS
   121  LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK LSTSSETVSS TAASKSGKTP ERTEASAKPR
   181  PHSDEYSKKI PPPKPKRNPN TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE
   241  EEPVYIEMVG NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT
   301  VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS DESPLTPLEV
   361  TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA LGPASATPAL SSSPPPPSTL
   421  YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV
   481  SQDGAKMVNA AVNTYGAAPG GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK
   541  STEELKVRSH STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP
   601  TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA NRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NYAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.6 nTPM
  • cerebral cortex: 2.6 nTPM
  • lung: 0.7 nTPM
  • skeletal muscle: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • parathyroid gland: 0.4 nTPM

Single-cell type

  • retinal bipolar cells: 555 nCPM
  • brain inhibitory neurons: 315 nCPM
  • corticotrophs: 208 nCPM
  • other brain neurons: 200 nCPM
  • thyrotrophs: 198 nCPM
  • lactotrophs: 155 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 32 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 19 nTPM
  • thalamus: 19 nTPM
  • spinal cord: 19 nTPM
  • basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NYAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NYAP2 as an antibody target. Whether an autoantibody or antibody against NYAP2 could matter depends on whether native NYAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NYAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NYAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NYAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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