Seroatlas · Human Serome Atlas

NYAP1

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

Also known as: C7orf51, FLJ37538, KIAA1486L, NYAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVC0
Gene: NYAP1
Ensembl: ENSG00000166924
Chromosome: 7
Canonical length: 841 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

841 residues, UniProt reviewed canonical sequence.

>Q6ZVC0|NYAP1
     1  MNLLYRKTKL EWRQHKEEEA KRSSSKEVAP AGSAGPAAGQ GPGVRVRDIA SLRRSLRMGF
    61  MTMPASQEHT PHPCRSAMAP RSLSCHSVGS MDSVGGGPGG ASGGLTEDSS TRRPPAKPRR
   121  HPSTKLSMVG PGSGAETPPS KKAGSQKPTP EGRESSRKVP PQKPRRSPNT QLSVSFDESC
   181  PPGPSPRGGN LPLQRLTRGS RVAGDPDVGA QEEPVYIEMV GDVFRGGGRS GGGLAGPPLG
   241  GGGPTPPAGA DSDSEESEAI YEEMKYPLPE EAGEGRANGP PPLTATSPPQ QPHALPPHAH
   301  RRPASALPSR RDGTPTKTTP CEIPPPFPNL LQHRPPLLAF PQAKSASRTP GDGVSRLPVL
   361  CHSKEPAGST PAPQVPARER ETPPPPPPPP AANLLLLGPS GRARSHSTPL PPQGSGQPRG
   421  ERELPNSHSM ICPKAAGAPA APPAPAALLP GPPKDKAVSY TMVYSAVKVT THSVLPAGPP
   481  LGAGEPKTEK EISVLHGMLC TSSRPPVPGK TSPHGGAMGA AAGVLHHRGC LASPHSLPDP
   541  TVGPLTPLWT YPATAAGLKR PPAYESLKAG GVLNKGCGVG APSPMVKIQL QEQGTDGGAF
   601  ASISCAHVIA SAGTPEEEEE EVGAATFGAG WALQRKVLYG GRKAKELDKV EDGARAWNGS
   661  AEGPGKVERE DRGPGTSGIP VRSQGAEGLL ARIHHGDRGG SRTALPIPCQ TFPACHRNGD
   721  FTGGYRLGRS ASTSGVRQVV LHTPRPCSQP RDALSQPHPA LPLPLPLPPQ PARERDGKLL
   781  EVIERKRCVC KEIKARHRPD RGLCKQESMP ILPSWRRGPE PRKSGTPPCR RQHTVLWDTA
   841  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NYAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 35 nTPM
cerebellum: 28 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 26 nTPM
hypothalamus: 25 nTPM
amygdala: 22 nTPM

Single-cell type

sertoli cells: 33 nCPM
epicardial cells: 32 nCPM
thyrotrophs: 30 nCPM
lactotrophs: 29 nCPM
epididymal basal cells: 21 nCPM
somatotrophs: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 96 nTPM
hippocampal formation: 73 nTPM
white matter: 66 nTPM
basal ganglia: 65 nTPM
pons: 64 nTPM
amygdala: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of NYAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NYAP1 as an antibody target. Whether an autoantibody or antibody against NYAP1 could matter depends on whether native NYAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NYAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NYAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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