Seroatlas · Human Serome Atlas

PKN3

Serine/threonine-protein kinase N3

Also known as: PKN3_HUMAN, PKNbeta, UTDP4-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P5Z2
Gene: PKN3
Ensembl: ENSG00000160447
Chromosome: 9
Canonical length: 889 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

889 residues, UniProt reviewed canonical sequence.

>Q6P5Z2|PKN3
     1  MEEGAPRQPG PSQWPPEDEK EVIRRAIQKE LKIKEGVENL RRVATDRRHL GHVQQLLRSS
    61  NRRLEQLHGE LRELHARILL PGPGPGPAEP VASGPRPWAE QLRARHLEAL RRQLHVELKV
   121  KQGAENMTHT CASGTPKERK LLAAAQQMLR DSQLKVALLR MKISSLEASG SPEPGPELLA
   181  EELQHRLHVE AAVAEGAKNV VKLLSSRRTQ DRKALAEAQA QLQESSQKLD LLRLALEQLL
   241  EQLPPAHPLR SRVTRELRAA VPGYPQPSGT PVKPTALTGT LQVRLLGCEQ LLTAVPGRSP
   301  AAALASSPSE GWLRTKAKHQ RGRGELASEV LAVLKVDNRV VGQTGWGQVA EQSWDQTFVI
   361  PLERARELEI GVHWRDWRQL CGVAFLRLED FLDNACHQLS LSLVPQGLLF AQVTFCDPVI
   421  ERRPRLQRQE RIFSKRRGQD FLRASQMNLG MAAWGRLVMN LLPPCSSPST ISPPKGCPRT
   481  PTTLREASDP ATPSNFLPKK TPLGEEMTPP PKPPRLYLPQ EPTSEETPRT KRPHMEPRTR
   541  RGPSPPASPT RKPPRLQDFR CLAVLGRGHF GKVLLVQFKG TGKYYAIKAL KKQEVLSRDE
   601  IESLYCEKRI LEAVGCTGHP FLLSLLACFQ TSSHACFVTE FVPGGDLMMQ IHEDVFPEPQ
   661  ARFYVACVVL GLQFLHEKKI IYRDLKLDNL LLDAQGFLKI ADFGLCKEGI GFGDRTSTFC
   721  GTPEFLAPEV LTQEAYTRAV DWWGLGVLLY EMLVGECPFP GDTEEEVFDC IVNMDAPYPG
   781  FLSVQGLEFI QKLLQKCPEK RLGAGEQDAE EIKVQPFFRT TNWQALLART IQPPFVPTLC
   841  GPADLRYFEG EFTGLPPALT PPAPHSLLTA RQQAAFRDFD FVSERFLEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 15 nTPM
breast: 13 nTPM
adipose tissue: 12 nTPM
salivary gland: 11 nTPM
cerebellum: 11 nTPM
lung: 11 nTPM

Single-cell type

breast lactating cells: 149 nCPM
vascular endothelial cells: 61 nCPM
lymphatic endothelial cells: 38 nCPM
respiratory deuterosomal cells: 24 nCPM
megakaryocyte progenitors: 20 nCPM
paneth cells: 19 nCPM

Immune cell

neutrophil: 0.4 nTPM
eosinophil: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM
NK-cell: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

cerebellum: 8.1 nTPM
thalamus: 7.6 nTPM
amygdala: 5.6 nTPM
pons: 5.4 nTPM
medulla oblongata: 5.2 nTPM
midbrain: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKN3 as an antibody target. Whether an autoantibody or antibody against PKN3 could matter depends on whether native PKN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PKN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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