Seroatlas · Human Serome Atlas

APOBEC3F

DNA dC->dU-editing enzyme APOBEC-3F

Also known as: ABC3F_HUMAN, ARP8, BK150C2.4.MRNA, KA6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUX4
Gene
APOBEC3F
Ensembl
ENSG00000128394
Chromosome
22
Canonical length
373 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q8IUX4|APOBEC3F
     1  MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPRLD AKIFRGQVYS
    61  QPEHHAEMCF LSWFCGNQLP AYKCFQITWF VSWTPCPDCV AKLAEFLAEH PNVTLTISAA
   121  RLYYYWERDY RRALCRLSQA GARVKIMDDE EFAYCWENFV YSEGQPFMPW YKFDDNYAFL
   181  HRTLKEILRN PMEAMYPHIF YFHFKNLRKA YGRNESWLCF TMEVVKHHSP VSWKRGVFRN
   241  QVDPETHCHA ERCFLSWFCD DILSPNTNYE VTWYTSWSPC PECAGEVAEF LARHSNVNLT
   301  IFTARLYYFW DTDYQEGLRS LSQEGASVEI MGYKDFKYCW ENFVYNDDEP FKPWKGLKYN
   361  FLFLDSKLQE ILE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC3F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 15 nTPM
  • tonsil: 14 nTPM
  • spleen: 11 nTPM
  • appendix: 8.6 nTPM
  • ovary: 8.4 nTPM
  • testis: 8.4 nTPM

Single-cell type

  • megakaryocytes: 25 nCPM
  • epididymal clear cells: 25 nCPM
  • salivary ionocytes: 23 nCPM
  • b-cells: 22 nCPM
  • cholangiocytes: 21 nCPM
  • epididymal basal cells: 20 nCPM

Immune cell

  • naive B-cell: 34 nTPM
  • memory B-cell: 28 nTPM
  • NK-cell: 15 nTPM
  • non-classical monocyte: 15 nTPM
  • MAIT T-cell: 9.9 nTPM
  • eosinophil: 9.4 nTPM

Brain region

  • choroid plexus: 8.1 nTPM
  • medulla oblongata: 7.5 nTPM
  • white matter: 7 nTPM
  • midbrain: 6.6 nTPM
  • thalamus: 6.5 nTPM
  • pons: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
-1.29
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APOBEC3F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC3F as an antibody target. Whether an autoantibody or antibody against APOBEC3F could matter depends on whether native APOBEC3F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC3F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC3F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOBEC3F. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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