Mu homology domain
IPR028565
Definition
The mu homology domain (MHD) is an ~280 residue protein-protein interaction module, which is found in endocytotic proteins involved in clathrin-mediated endocytosis [[cite:PMID:11381094], [cite:PMID:11454741], [cite:PMID:14726597], [cite:PMID:19713939]]: Mu subunits of adaptor protein (AP) complexes, AP-1, AP-2, AP-3, and AP-4. Proteins of the stonin family. Proteins of the muniscin family: Syp1, FCHO1/2 and SGIP1. The MHD domain has an elongated, banana-shaped, all β-sheet structure. It can be considered as two β-sandwich subdomains (A and B), with subdomain B inserted between strands 6 and 15 of subdomain A, and joined edge to edge such that the convex surface is a continuous nine-stranded mixed β-sheet that runs the whole length of the molecule. The tyrosine based signal binds to a site on the surface of two parallel β-sheet strands (β1 and β16) in subdomain A [[cite:PMID:19713939], [cite:PMID:9812899]].
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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