AP-2 complex subunit mu, C-terminal superfamily
IPR036168
Definition
This superfamily describes the C-terminal domain of the Mu subunit (Mu2-adaptin, AP50) of adaptor protein (AP) complexes AP-1, AP-2, AP-3, and AP-4. It has an elongated, banana-shaped, all β-sheet structure. It can be considered as two β-sandwich subdomains (A and B), with subdomain B inserted between strands 6 and 15 of subdomain A, and joined edge to edge such that the convex surface is a continuous nine-stranded mixed β-sheet that runs the whole length of the molecule. The tyrosine based signal binds to a site on the surface of two parallel β-sheet strands (β1 and β16) in subdomain A [[cite:PMID:19713939], [cite:PMID:9812899]].
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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