Seroatlas · Human Serome Atlas

BCL2L10

Bcl-2-like protein 10

Also known as: B2L10_HUMAN, BCL-B, Boo, Diva

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD36
Gene
BCL2L10
Ensembl
ENSG00000137875
Chromosome
15
Canonical length
204 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9HD36|BCL2L10
     1  MVDQLRERTT MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH
    61  RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK
   121  WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWDGFCHFF RTPFPLAFWR
   181  KQLVQAFLSC LLTTAFIYLW TRLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • liver: 9.2 nTPM
  • skin: 6.5 nTPM
  • vagina: 3.5 nTPM
  • esophagus: 3.4 nTPM
  • basal ganglia: 3.3 nTPM
  • cervix: 3.2 nTPM

Single-cell type

  • oocytes: 286 nCPM
  • esophageal suprabasal cells: 23 nCPM
  • esophageal basal cells: 16 nCPM
  • enterocytes: 9.7 nCPM
  • suprabasal keratinocytes: 8.8 nCPM
  • basal keratinocytes: 8.1 nCPM

Immune cell

  • basophil: 1.4 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • memory B-cell: 0.4 nTPM
  • myeloid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 3.3 nTPM
  • basal ganglia: 3.1 nTPM
  • amygdala: 2.3 nTPM
  • cerebral cortex: 1.9 nTPM
  • hippocampal formation: 1.6 nTPM
  • cerebellum: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0.01
gnomAD missense Z
0.31
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L10 as an antibody target. Whether an autoantibody or antibody against BCL2L10 could matter depends on whether native BCL2L10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL2L10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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