Seroatlas · Human Serome Atlas

SLC26A6

Solute carrier family 26 member 6

Also known as: DKFZp586E1422, S26A6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXS9
Gene
SLC26A6
Ensembl
ENSG00000225697
Chromosome
3
Canonical length
759 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

759 residues, UniProt reviewed canonical sequence.

>Q9BXS9|SLC26A6
     1  MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA PRTHQWRTWL
    61  QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV
   121  FGLYSSFYPV FIYFLFGTSR HISVGTFAVM SVMVGSVTES LAPQALNDSM INETARDAAR
   181  VQVASTLSVL VGLFQVGLGL IHFGFVVTYL SEPLVRGYTT AAAVQVFVSQ LKYVFGLHLS
   241  SHSGPLSLIY TVLEVCWKLP QSKVGTVVTA AVAGVVLVVV KLLNDKLQQQ LPMPIPGELL
   301  TLIGATGISY GMGLKHRFEV DVVGNIPAGL VPPVAPNTQL FSKLVGSAFT IAVVGFAIAI
   361  SLGKIFALRH GYRVDSNQEL VALGLSNLIG GIFQCFPVSC SMSRSLVQES TGGNSQVAGA
   421  ISSLFILLII VKLGELFHDL PKAVLAAIII VNLKGMLRQL SDMRSLWKAN RADLLIWLVT
   481  FTATILLNLD LGLVVAVIFS LLLVVVRTQM PHYSVLGQVP DTDIYRDVAE YSEAKEVRGV
   541  KVFRSSATVY FANAEFYSDA LKQRCGVDVD FLISQKKKLL KKQEQLKLKQ LQKEEKLRKQ
   601  AASPKGASVS INVNTSLEDM RSNNVEDCKM MQVSSGDKME DATANGQEDS KAPDGSTLKA
   661  LGLPQPDFHS LILDLGALSF VDTVCLKSLK NIFHDFREIE VEVYMAACHS PVVSQLEAGH
   721  FFDASITKKH LFASVHDAVT FALQHPRPVP DSPVSVTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 27 nTPM
  • colon: 27 nTPM
  • stomach: 25 nTPM
  • small intestine: 22 nTPM
  • rectum: 20 nTPM
  • kidney: 19 nTPM

Single-cell type

  • colonocytes: 59 nCPM
  • proximal tubule cells: 52 nCPM
  • enterocytes: 42 nCPM
  • goblet cells: 41 nCPM
  • mucous neck cells: 34 nCPM
  • enteric transient amplifying cells: 21 nCPM

Immune cell

  • classical monocyte: 11 nTPM
  • intermediate monocyte: 11 nTPM
  • non-classical monocyte: 10 nTPM
  • myeloid DC: 9 nTPM
  • basophil: 6.9 nTPM
  • plasmacytoid DC: 5.1 nTPM

Brain region

  • cerebral cortex: 6.8 nTPM
  • white matter: 5.5 nTPM
  • pons: 5.3 nTPM
  • medulla oblongata: 5 nTPM
  • thalamus: 4.8 nTPM
  • choroid plexus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC26A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A6 as an antibody target. Whether an autoantibody or antibody against SLC26A6 could matter depends on whether native SLC26A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A6 is annotated at the cell surface, where native SLC26A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC26A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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