Seroatlas · Human Serome Atlas

JOSD2

Josephin-2

Also known as: JOS2_HUMAN, SBBI54

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAC2
Gene: JOSD2
Ensembl: ENSG00000161677
Chromosome: 19
Canonical length: 188 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q8TAC2|JOSD2
     1  MSQAPGAQPS PPTVYHERQR LELCAVHALN NVLQQQLFSQ EAADEICKRL APDSRLNPHR
    61  SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ VLGLILNLPS PVSLGLLSLP
   121  LRRRHWVALR QVDGVYYNLD SKLRAPEALG DEDGVRAFLA AALAQGLCEV LLVVTKEVEE
   181  KGSWLRTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JOSD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 99 nTPM
midbrain: 71 nTPM
basal ganglia: 58 nTPM
hippocampal formation: 55 nTPM
amygdala: 53 nTPM
skeletal muscle: 51 nTPM

Single-cell type

esophageal apical cells: 265 nCPM
esophageal suprabasal cells: 227 nCPM
decidual stromal cells: 191 nCPM
enterocytes: 142 nCPM
respiratory ciliated cells: 140 nCPM
colonocytes: 135 nCPM

Immune cell

classical monocyte: 96 nTPM
eosinophil: 95 nTPM
intermediate monocyte: 94 nTPM
non-classical monocyte: 70 nTPM
myeloid DC: 70 nTPM
basophil: 56 nTPM

Brain region

white matter: 72 nTPM
medulla oblongata: 66 nTPM
cerebral cortex: 62 nTPM
pons: 59 nTPM
cerebellum: 59 nTPM
basal ganglia: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JOSD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AHCYL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JOSD2 as an antibody target. Whether an autoantibody or antibody against JOSD2 could matter depends on whether native JOSD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JOSD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JOSD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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