ADAMTS cysteine-rich domain

Definition

This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals [[cite:PMID:29885460],[cite:PMID:15094122]]. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues PMID:15987500. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, [pfam:PF08516]) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organisation [[cite:PMID:8995297],[cite:PMID:10464288]]. Members of the ADAMTS family have been implicated in a range of diseases [[cite:PMID:29885460],[cite:PMID:17265492],[cite:PMID:34268335]].

25 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (25 proteins: gene, accession, name)

• ADAMTS1
• ADAMTS10
• ADAMTS12
• ADAMTS13
• ADAMTS14
• ADAMTS15
• ADAMTS16
• ADAMTS17
• ADAMTS18
• ADAMTS2
• ADAMTS20
• ADAMTS3
• ADAMTS4
• ADAMTS5
• ADAMTS6
• ADAMTS7
• ADAMTS8
• ADAMTS9
• ADAMTSL1
• ADAMTSL2
• ADAMTSL3
• ADAMTSL4
• ADAMTSL5
• PAPLN
• THSD4