Seroatlas · Human Serome Atlas

LRRC7

Leucine-rich repeat-containing protein 7

Also known as: LRRC7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NW7
Gene: LRRC7
Canonical length: 1537 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1537 residues, UniProt reviewed canonical sequence.

>Q96NW7|LRRC7
     1  MTTKRKIIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE
    61  LPKQLFNCQA LRKLSIPDND LSNLPTTIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII
   121  EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL VKLRILELRE NHLKTLPKSM
   181  HKLAQLERLD LGNNEFGELP EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN
   241  RIETVDMDIS GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL
   301  LEEFDCSCNE LESLPSTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM SLRSNKLEFL
   361  PEEIGQMQKL RVLNLSDNRL KNLPFSFTKL KELAALWLSD NQSKALIPLQ TEAHPETKQR
   421  VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE EQRQQRMTVA FEFEDKKEDD ENAGKVKDLS
   481  CQAPWERGQR GITLQPARLS GDCCTPWARC DQQIQDMPVP QNDPQLAWGC ISGLQQERSM
   541  CTPLPVAAQS TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENSN
   601  PTANTEQTVK EKYEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP LYPPKLVLLG
   661  KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSGSS NTRVKVGSLQ TTAKDAVHNS
   721  LWGNRIAPSF PQPLDSKPLL SQREAVPPGN IPQRPDRLPM SDTFTDNWTD GSHYDNTGFV
   781  AEETTAENAN SNPLLSSKSR STSSHGRRPL IRQDRIVGVP LELEQSTHRH TPETEVPPSN
   841  PWQNWTRTPS PFEDRTAFPS KLETTPTTSP LPERKEHIKE STEIPSPFSP GVPWEYHDSN
   901  PNRSLSNVFS QIHCRPESSK GVISISKSTE RLSPLMKDIK SNKFKKSQSI DEIDIGTYKV
   961  YNIPLENYAS GSDHLGSHER PDKMLGPEHG MSSMSRSQSV PMLDDEMLTY GSSKGPQQQK
  1021  ASMTKKVYQF DQSFNPQGSV EVKAEKRIPP PFQHNPEYVQ QASKNIAKDL ISPRAYRGYP
  1081  PMEQMFSFSQ PSVNEDAVVN AQFASQGARA GFLRRADSLV SATEMAMFRR VNEPHELPPT
  1141  DRYGRPPYRG GLDRQSSVTV TESQFLKRNG RYEDEHPSYQ EVKAQAGSFP VKNLTQRRPL
  1201  SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKPSDNSDL KTRPTPVKGE
  1261  ESCGKMPADW RQQLLRHIEA RRLDRNAAYK HNTVNLGMLP YGGISAMHAG RSMTLNLQTK
  1321  SKFDHQELPL QKTPSQQSNI LDNGQEDVSP SGQWNPYPLG RRDVPPDTIT KKAGSHIQTL
  1381  MGSQSLQHRS REQQPYEGNI NKVTIQQFQS PLPIQIPSSQ ATRGPQPGRC LIQTKGQRSM
  1441  DGYPEQFCVR IEKNPGLGFS ISGGISGQGN PFKPSDKGIF VTRVQPDGPA SNLLQPGDKI
  1501  LQANGHSFVH MEHEKAVLLL KSFQNTVDLV IQRELTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 7.9 nTPM
basal ganglia: 6.4 nTPM
hippocampal formation: 5.8 nTPM
amygdala: 4.9 nTPM
hypothalamus: 3.2 nTPM
midbrain: 2.3 nTPM

Single-cell type

brain inhibitory neurons: 1,786 nCPM
brain excitatory neurons: 1,308 nCPM
oligodendrocyte progenitor cells: 1,214 nCPM
retinal bipolar cells: 762 nCPM
other brain neurons: 761 nCPM
oligodendrocytes: 442 nCPM

Immune cell

eosinophil: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 101 nTPM
hippocampal formation: 96 nTPM
basal ganglia: 93 nTPM
thalamus: 75 nTPM
amygdala: 69 nTPM
white matter: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC7.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

LRRC7-associated obesity and neurodevelopmental disorder
Intellectual developmental disorder, autosomal dominant 77
LRRC7-associated disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 3.6
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC7 as an antibody target. Whether an autoantibody or antibody against LRRC7 could matter depends on whether native LRRC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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