Polycomb group and chromatin remodeling factors
IPR050548
Definition
This family of proteins includes Polycomb group (PcG) components and related factors that are involved in chromatin remodeling and transcriptional repression. They play a crucial role in maintaining the repressive state of genes, including homeotic genes, throughout development. Members of this family are characterized by their ability to recognize and bind specific methylated lysine residues on histone proteins, acting as 'readers' of post-translational modifications. This binding can lead to chromatin compaction and gene silencing. Some members also participate in DNA damage repair by promoting homologous recombination. Additionally, they may be involved in cell proliferation, differentiation, and the regulation of ubiquitin-dependent protein degradation. The family includes proteins with MBT repeats, SAM domains, and other domains that contribute to their function in gene regulation and chromatin structure.
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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