Seroatlas · Human Serome Atlas

L3MBTL4

Lethal(3)malignant brain tumor-like protein 4

Also known as: FLJ35936, HsT1031, LMBL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA19
Gene: L3MBTL4
Ensembl: ENSG00000154655
Chromosome: 18
Canonical length: 623 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>Q8NA19|L3MBTL4
     1  MKQPNRKRKL NMDSKERLDQ DGRLEQAEEE KKPKDSTTPL SHVPSAAAQG AWSWEWYLKE
    61  QKAVAAPVEL FSKDQSFPEH ENGFQIGMRL EGIDPRHPSV FCVLSVAEVC GYRLRLHFDG
   121  YLSCYDFWTN AGSPDIHPVG WCEKTKHELH IPKGYRKDKF VWMDYLKACK LQNAPKKLFR
   181  NRSPNGPMSK EFQVGMKLEA VDRKNPSLVC VATIADIVED RLLVHFDNWD DSYDYWCDVN
   241  SPYVQPVGWC QENGRTLIAP QGYPNPENFS WTEYLEATQT NAVPAKVFKM RLPHGFLPNM
   301  KLEVVDKRNP RLIRVATIVD VDDQRVKVHF DGWDHKYDYW VEADSPDIHP IGWCDVTGHP
   361  LEVPQRTNDL KILPGQAVCP TPGCRGIGHI RGPRYSGHHS AFGCPYSDMN LKKEATLHDR
   421  LREQTQANLE SDSSHSKSKS LCSLNFNGKH EKVNSQPRLV QQAKCLKIKG KEDIDLDNLF
   481  RVLVLHPRGL EYSVEQAQQV LHQSVSMSTV SAHPFRDLPL GREQHCKLLP GVADIRASQV
   541  ARWTVDEVAE FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ TDIVKVMKIK LGPALKIYNS
   601  ILMFRHSQEL PEEDIASGQE VRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against L3MBTL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
liver: 8.2 nTPM
parathyroid gland: 8 nTPM
skin: 6.9 nTPM
kidney: 6.6 nTPM
pancreas: 6.1 nTPM

Single-cell type

sertoli cells: 1,133 nCPM
proximal tubule cells: 964 nCPM
pituitary stem cells: 692 nCPM
gonadotrophs: 628 nCPM
renal collecting duct intercalated cells: 460 nCPM
microglia: 359 nCPM

Immune cell

NK-cell: 3.6 nTPM
naive B-cell: 2.5 nTPM
classical monocyte: 1.1 nTPM
non-classical monocyte: 0.8 nTPM
gdT-cell: 0.7 nTPM
myeloid DC: 0.7 nTPM

Brain region

white matter: 42 nTPM
basal ganglia: 37 nTPM
midbrain: 32 nTPM
cerebral cortex: 31 nTPM
amygdala: 28 nTPM
hypothalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads L3MBTL4 as an antibody target. Whether an autoantibody or antibody against L3MBTL4 could matter depends on whether native L3MBTL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

L3MBTL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label L3MBTL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...