SCML2

Protein identityUniProt · HPA

UniProt accession

Q9UQR0

Gene

SCML2

Ensembl

ENSG00000102098

Chromosome

X

Canonical length

700 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

700 residues, UniProt reviewed canonical sequence.

>Q9UQR0|SCML2
     1  MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV
    61  NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT
   121  CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA
   181  IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP
   241  GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS
   301  VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY
   361  VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG
   421  EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH
   481  DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL
   541  SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF
   601  QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI
   661  DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCML2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.13

gnomAD pLI

1

gnomAD missense Z

2.4

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anatomical structure morphogenesis
• negative regulation of DNA-templated transcription

Molecular functions

• chromatin binding
• histone binding

Cellular components

• nucleus
• PcG protein complex

Protein domainsUniProt · Pfam · InterPro

• Sterile alpha motif domain
• Mbt repeat domain
• Sterile alpha motif/pointed domain superfamily
• SLED domain
• Polycomb group protein, RNA binding region
• SLED domain superfamily
• Sex comb on midleg-like, SAM domain
• Polycomb group and chromatin remodeling factors
• SAM domain (Sterile alpha motif)
• mbt repeat
• SLED domain
• RNA binding Region

KeywordsUniProt

• Isopeptide bond
• Nucleus
• Phosphoprotein
• Repeat
• Repressor
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SCML2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• USP7