Seroatlas · Human Serome Atlas

SFMBT1

Scm-like with four MBT domains protein 1

Also known as: DKFZp434L243, RU1, SFMBT, SMBT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHJ3
Gene: SFMBT1
Ensembl: ENSG00000163935
Chromosome: 3
Canonical length: 866 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

866 residues, UniProt reviewed canonical sequence.

>Q9UHJ3|SFMBT1
     1  MNGEQQLDAD AGSGMEEVEL SWEDYLEETG STAVPYGSFK HVDTRLQNGF APGMKLEVAV
    61  RTDPETYWVA TVITTCEQLL LLRYDGYGED RRADFWCDIR KADLYPIGWC EQNKKTLEAP
   121  EGIRDKVSDW DEFLRQTLIG ACSPPVPLLE GLRNGRNPLD LIAPGSRLEC QAFQDSLSTW
   181  IVTVVENIGG RLKLRYEGLE SSDNYEHWLY YLDPFLHHVG WAAQQGYELQ PPSAIRHLKN
   241  EAEWQEILAK VKEEEEEPLP SYLFKDKQVI GIHTFSVNMK LEAVDPWSPF GISPATVVKV
   301  FDEKYFLVEM DDLRPENHAR RSFVCHADSP GIFPVQWSLK NGLHISPPPG YPSQDFDWAD
   361  YLKQCGAEAA PQRCFPPLIS EHEFKENMKL EAVNPILPEE VCVATITAVR GSYLWLQLEG
   421  SKKPIPECIV SVESMDIFPL GWCETNGHPL STPRRARVYK QRKIAVVQPE KQVPSSRTVH
   481  EGLRNQELNS TESVMINGKY CCPKIYFNHR CFSGPYLNKG RIAELPQCVG PGNCVLVLRE
   541  VLTLLINAAY KPSRVLRELQ LDKDSVWHGC GEVLKAKYKG KSYRATVEIV KTADRVTEFC
   601  RQTCIKLECC PNLFGPRMVL DKCSENCSVL TKTKYTHYYG KKKNKRIGRP PGGHSNLACA
   661  LKKASKRRKR RKNVFVHKKK RSSASVDNTP AGSPQGSGGE DEDDPDEGDD DSLSEGSTSE
   721  QQDELQEESE MSEKKSCSSS PTQSEISTSL PPDRQRRKRE LRTFSFSDDE NKPPSPKEIR
   781  IEVAERLHLD SNPLKWSVAD VVRFIRSTDC APLARIFLDQ EIDGQALLLL TLPTVQECMD
   841  LKLGPAIKLC HHIERIKFAF YEQFAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFMBT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

testis: 43 nTPM
skeletal muscle: 12 nTPM
parathyroid gland: 11 nTPM
pancreas: 8.5 nTPM
tongue: 8.1 nTPM
tonsil: 7.9 nTPM

Single-cell type

late primary spermatocytes: 209 nCPM
late spermatids: 81 nCPM
gonadotrophs: 80 nCPM
respiratory deuterosomal cells: 73 nCPM
early primary spermatocytes: 70 nCPM
lactotrophs: 62 nCPM

Immune cell

eosinophil: 9.2 nTPM
memory B-cell: 6.3 nTPM
naive B-cell: 5.3 nTPM
naive CD8 T-cell: 4.1 nTPM
memory CD4 T-cell: 4 nTPM
naive CD4 T-cell: 3.7 nTPM

Brain region

cerebellum: 14 nTPM
choroid plexus: 11 nTPM
hypothalamus: 10 nTPM
white matter: 10 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.94
gnomAD missense Z: 2.05
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell differentiation
chromatin organization
negative regulation of DNA-templated transcription
spermatogenesis
negative regulation of muscle organ development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif domain
Mbt repeat domain
Sterile alpha motif/pointed domain superfamily
SLED domain
Scm-like with four MBT domains protein 1/2, SAM domain
SLED domain superfamily
Polycomb group and chromatin remodeling factors
SAM domain (Sterile alpha motif)
mbt repeat
SLED domain
Scm-like with four MBT domains protein 1, third MBT repeat
Scm-like with four MBT domains protein 1, second MBT repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFMBT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFMBT1 as an antibody target. Whether an autoantibody or antibody against SFMBT1 could matter depends on whether native SFMBT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFMBT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFMBT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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