Seroatlas · Human Serome Atlas

SAMD13

Sterile alpha motif domain-containing protein 13

Also known as: SAM13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VXD3
Gene
SAMD13
Ensembl
ENSG00000203943
Chromosome
1
Canonical length
122 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

No narrative summary is available for SAMD13 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q5VXD3|SAMD13
     1  MANSLLEGVF AEVKEPCSLP MLSVDMENKE NGSVGVKNSM ENGRPPDPAD WAVMDVVNYF
    61  RTVGFEEQAS AFQEQEIDGK SLLLMTRNDV LTGLQLKLGP ALKIYEYHVK PLQTKHLKNN
   121  SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 21 nTPM
  • colon: 18 nTPM
  • salivary gland: 17 nTPM
  • testis: 12 nTPM
  • thyroid gland: 9.1 nTPM
  • stomach: 5.7 nTPM

Single-cell type

  • colonocytes: 59 nCPM
  • late primary spermatocytes: 55 nCPM
  • adrenal medulla cells: 53 nCPM
  • parietal cells: 51 nCPM
  • enteric stem cells: 45 nCPM
  • enteric transient amplifying cells: 44 nCPM

Immune cell

  • basophil: 13 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • myeloid DC: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • NK-cell: 0.5 nTPM

Brain region

  • white matter: 33 nTPM
  • choroid plexus: 23 nTPM
  • amygdala: 22 nTPM
  • cerebral cortex: 22 nTPM
  • thalamus: 20 nTPM
  • hippocampal formation: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0.01
gnomAD missense Z
0.86
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD13 as an antibody target. Whether an autoantibody or antibody against SAMD13 could matter depends on whether native SAMD13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAMD13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...