Seroatlas · Human Serome Atlas

PHC3

Polyhomeotic-like protein 3

Also known as: EDR3, FLJ12729, FLJ12967, HPH3, PHC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDX5
Gene: PHC3
Ensembl: ENSG00000173889
Chromosome: 3
Canonical length: 983 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of PRC1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

983 residues, UniProt reviewed canonical sequence.

>Q8NDX5|PHC3
     1  MDTEPNPGTS SVSTTTSSTT TTTITTSSSR MQQPQISVYS GSDRHAVQVI QQALHRPPSS
    61  AAQYLQQMYA AQQQHLMLHT AALQQQHLSS SQLQSLAAVQ ASLSSGRPST SPTGSVTQQS
   121  SMSQTSINLS TSPTPAQLIS RSQASSSTSG SITQQTMLLG STSPTLTASQ AQMYLRAQML
   181  IFTPATTVAA VQSDIPVVSS SSSSSCQSAA TQVQNLTLRS QKLGVLSSSQ NGPPKSTSQT
   241  QSLTICHNKT TVTSSKISQR DPSPESNKKG ESPSLESRST AVTRTSSIHQ LIAPASYSPI
   301  QPHSLIKHQQ IPLHSPPSKV SHHQLILQQQ QQQIQPITLQ NSTQDPPPSQ HCIPLQNHGL
   361  PPAPSNAQSQ HCSPIQSHPS PLTVSPNQSQ SAQQSVVVSP PPPHSPSQSP TIIIHPQALI
   421  QPHPLVSSAL QPGPNLQQST ANQVQATAQL NLPSHLPLPA SPVVHIGPVQ QSALVSPGQQ
   481  IVSPSHQQYS SLQSSPIPIA SPPQMSTSPP AQIPPLPLQS MQSLQVQPEI LSQGQVLVQN
   541  ALVSEEELPA AEALVQLPFQ TLPPPQTVAV NLQVQPPAPV DPPVVYQVED VCEEEMPEES
   601  DECVRMDRTP PPPTLSPAAI TVGRGEDLTS EHPLLEQVEL PAVASVSASV IKSPSDPSHV
   661  SVPPPPLLLP AATTRSNSTS MHSSIPSIEN KPPQAIVKPQ ILTHVIEGFV IQEGLEPFPV
   721  SRSSLLIEQP VKKRPLLDNQ VINSVCVQPE LQNNTKHADN SSDTEMEDMI AEETLEEMDS
   781  ELLKCEFCGK MGYANEFLRS KRFCTMSCAK RYNVSCSKKF ALSRWNRKPD NQSLGHRGRR
   841  PSGPDGAARE HILRQLPITY PSAEEDLASH EDSVPSAMTT RLRRQSERER ERELRDVRIR
   901  KMPENSDLLP VAQTEPSIWT VDDVWAFIHS LPGCQDIADE FRAQEIDGQA LLLLKEDHLM
   961  SAMNIKLGPA LKICARINSL KES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 48 nTPM
retina: 39 nTPM
lymph node: 17 nTPM
thymus: 16 nTPM
thyroid gland: 16 nTPM
parathyroid gland: 14 nTPM

Single-cell type

neutrophil progenitors: 499 nCPM
rod photoreceptor cells: 320 nCPM
myonuclei: 316 nCPM
choroid plexus epithelial cells: 261 nCPM
adipocytes: 250 nCPM
podocytes: 243 nCPM

Immune cell

plasmacytoid DC: 26 nTPM
eosinophil: 26 nTPM
naive B-cell: 22 nTPM
T-reg: 20 nTPM
memory B-cell: 17 nTPM
gdT-cell: 16 nTPM

Brain region

cerebellum: 136 nTPM
hypothalamus: 105 nTPM
white matter: 103 nTPM
cerebral cortex: 94 nTPM
basal ganglia: 93 nTPM
pons: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 1.72
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHC3 as an antibody target. Whether an autoantibody or antibody against PHC3 could matter depends on whether native PHC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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