Copine

Definition

Copines are a widely distributed class of Ca2+-dependent lipid-binding proteins. Most have a characteristic domain structure: two C2 domains in the N-terminal region and a von Willebrand A (VWA) domain in the C-terminal region. They are potentially involved in membrane trafficking, protein-protein interactions, and perhaps even cell division and growth [[cite:PMID:9430674], [cite:PMID:12440769]]. In plants, they are known as BONZAI proteins PMID:27484220. The copine family in plants may have effects in promoting growth and development in addition to repressing cell death [[cite:PMID:11544183], [cite:PMID:16367962]]. Caenorhabditis elegans copine, also known as Nra1, is Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole PMID:15990870.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• CPNE1
• CPNE2
• CPNE3
• CPNE4
• CPNE5
• CPNE6
• CPNE7
• CPNE8
• CPNE9