GT10-like, C-terminal domain superfamily

Definition

Structural domains comprising this superfamily share the structure of the C-terminal domain of Glycosyltransferase family 10 (GT10). The C-terminal domain plays an important role in acceptor binding and specificity PMID:12676935. Glycosyltransferase family 10 ([cazy:GT10]) comprises enzymes with two known activities; galactoside 3(4)-L-fucosyltransferase ([ec:2.4.1.65]) and galactoside 3-fucosyltransferase ([ec:2.4.1.152]). The galactoside 3-fucosyltransferases display similarities with the alpha-2 and alpha-6-fucosyltranferases PMID:9451017. The biosynthesis of the carbohydrate antigen sialyl Lewis X (sLe(x)) is dependent on the activity of an galactoside 3-fucosyltransferase. This enzyme catalyses the transfer of fucose from GDP-beta-fucose to the 3-OH of N-acetylglucosamine present in lactosamine acceptors PMID:9042366.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• FUT10
• FUT11
• FUT3
• FUT4
• FUT5
• FUT6
• FUT7
• FUT9