Seroatlas · Human Serome Atlas

FUT10

GDP-fucose protein O-fucosyltransferase 3

Also known as: OFUT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P4F1
Gene: FUT10
Ensembl: ENSG00000172728
Chromosome: 8
Canonical length: 479 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q6P4F1|FUT10
     1  MVRIQRRKLL ASCLCVTATV FLLVTLQVMV ELGKFERKEF KSSSLQDGHT KMEEAPTHLN
    61  SFLKKEGLTF NRKRKWELDS YPIMLWWSPL TGETGRLGQC GADACFFTIN RTYLHHHMTK
   121  AFLFYGTDFN IDSLPLPRKA HHDWAVFHEE SPKNNYKLFH KPVITLFNYT ATFSRHSHLP
   181  LTTQYLESIE VLKSLRYLVP LQSKNKLRKR LAPLVYVQSD CDPPSDRDSY VRELMTYIEV
   241  DSYGECLRNK DLPQQLKNPA SMDADGFYRI IAQYKFILAF ENAVCDDYIT EKFWRPLKLG
   301  VVPVYYGSPS ITDWLPSNKS AILVSEFSHP RELASYIRRL DSDDRLYEAY VEWKLKGEIS
   361  NQRLLTALRE RKWGVQDVNQ DNYIDAFECM VCTKVWANIR LQEKGLPPKR WEAEDTHLSC
   421  PEPTVFAFSP LRTPPLSSLR EMWISSFEQS KKEAQALRWL VDRNQNFSSQ EFWGLVFKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 4.8 nTPM
retina: 4.8 nTPM
ovary: 4.7 nTPM
cervix: 3.8 nTPM
basal ganglia: 3.3 nTPM
placenta: 3.3 nTPM

Single-cell type

late spermatids: 434 nCPM
early spermatids: 234 nCPM
late primary spermatocytes: 165 nCPM
astrocytes: 98 nCPM
bergmann glia: 94 nCPM
müller glia: 92 nCPM

Immune cell

T-reg: 1.7 nTPM
NK-cell: 1.6 nTPM
MAIT T-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM
myeloid DC: 1.3 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

midbrain: 14 nTPM
thalamus: 13 nTPM
basal ganglia: 12 nTPM
medulla oblongata: 12 nTPM
amygdala: 11 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.68
DepMap mean gene effect: 0.12
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT10 as an antibody target. Whether an autoantibody or antibody against FUT10 could matter depends on whether native FUT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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