Seroatlas · Human Serome Atlas

FUT6

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6

Also known as: FCT3A, FLJ40754, FT1A, FucT-VI, FUT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51993
Gene: FUT6
Ensembl: ENSG00000156413
Chromosome: 19
Canonical length: 359 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P51993|FUT6
     1  MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF PDSTGTPAHS
    61  IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL
   121  PRSPRRQGQR WIWFSMESPS HCWQLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH
   181  PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY
   241  KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD
   301  LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ TRGIAAWFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

esophagus: 77 nTPM
salivary gland: 44 nTPM
kidney: 33 nTPM
duodenum: 27 nTPM
vagina: 26 nTPM
small intestine: 25 nTPM

Single-cell type

esophageal apical cells: 518 nCPM
enterocytes: 131 nCPM
proximal tubule cells: 129 nCPM
goblet cells: 89 nCPM
colonocytes: 57 nCPM
paneth cells: 54 nCPM

Immune cell

basophil: 1.2 nTPM
NK-cell: 0.5 nTPM
neutrophil: 0.3 nTPM
eosinophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 1.1 nTPM
cerebellum: 0.7 nTPM
cerebral cortex: 0.7 nTPM
white matter: 0.7 nTPM
amygdala: 0.6 nTPM
basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.71
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT6 as an antibody target. Whether an autoantibody or antibody against FUT6 could matter depends on whether native FUT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT6 is annotated as secreted, so native FUT6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FUT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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