Seroatlas · Human Serome Atlas

FUT7

Alpha-(1,3)-fucosyltransferase 7

Also known as: FUT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q11130
Gene
FUT7
Ensembl
ENSG00000180549
Chromosome
9
Canonical length
342 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q11130|FUT7
     1  MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL VWHWPFTDQP
    61  PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT RRSHLPLAQR PRGQPWVWAS
   121  MESPSHTHGL SHLRGIFNWV LSYRRDSDIF VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF
   181  QERQLRARLY RQLAPHLRVD VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK
   241  FWRNALVAGT VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA
   301  WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 9.2 nTPM
  • lymph node: 4.3 nTPM
  • bone marrow: 3.7 nTPM
  • tonsil: 3 nTPM
  • cerebellum: 2.3 nTPM
  • appendix: 1.6 nTPM

Single-cell type

  • pdcs: 91 nCPM
  • neutrophils: 68 nCPM
  • cdc: 13 nCPM
  • neutrophil progenitors: 12 nCPM
  • monocyte progenitors: 8.9 nCPM
  • thymocytes: 5.9 nCPM

Immune cell

  • plasmacytoid DC: 210 nTPM
  • NK-cell: 127 nTPM
  • neutrophil: 92 nTPM
  • T-reg: 91 nTPM
  • MAIT T-cell: 53 nTPM
  • memory CD4 T-cell: 52 nTPM

Brain region

  • white matter: 6.6 nTPM
  • medulla oblongata: 5.7 nTPM
  • basal ganglia: 5.1 nTPM
  • cerebral cortex: 4.9 nTPM
  • midbrain: 4 nTPM
  • thalamus: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT7 as an antibody target. Whether an autoantibody or antibody against FUT7 could matter depends on whether native FUT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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