Seroatlas · Human Serome Atlas

FUT11

GDP-fucose protein O-fucosyltransferase 4

Also known as: MGC33202, OFUT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495W5
Gene: FUT11
Ensembl: ENSG00000196968
Chromosome: 10
Canonical length: 492 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear membrane,Golgi apparatus
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Implicated in stomach cancer. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q495W5|FUT11
     1  MAAGPIRVVL VLLGVLSVCA ASGHGSVAER EAGGEAEWAE PWDGAVFRPP SALGAVGVTR
    61  SSGTPRPGRE EAGDLPVLLW WSPGLFPHFP GDSERIECAR GACVASRNRR ALRDSRTRAL
   121  LFYGTDFRAS AAPLPRLAHQ SWALLHEESP LNNFLLSHGP GIRLFNLTST FSRHSDYPLS
   181  LQWLPGTAYL RRPVPPPMER AEWRRRGYAP LLYLQSHCDV PADRDRYVRE LMRHIPVDSY
   241  GKCLQNRELP TARLQDTATA TTEDPELLAF LSRYKFHLAL ENAICNDYMT EKLWRPMHLG
   301  AVPVYRGSPS VRDWMPNNHS VILIDDFESP QKLAEFIDFL DKNDEEYMKY LAYKQPGGIT
   361  NQFLLDSLKH REWGVNDPLL PNYLNGFECF VCDYELARLD AEKAHAASPG DSPVFEPHIA
   421  QPSHMDCPVP TPGFGNVEEI PENDSWKEMW LQDYWQGLDQ GEALTAMIHN NETEQTKFWD
   481  YLHEIFMKRQ HL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

placenta: 16 nTPM
spleen: 9.7 nTPM
testis: 9.5 nTPM
retina: 9.3 nTPM
adipose tissue: 8.8 nTPM
heart muscle: 8.8 nTPM

Single-cell type

late spermatids: 372 nCPM
esophageal apical cells: 254 nCPM
early spermatids: 226 nCPM
kupffer cells: 49 nCPM
pancreatic islet cells: 49 nCPM
extravillous trophoblasts: 48 nCPM

Immune cell

gdT-cell: 20 nTPM
memory CD8 T-cell: 14 nTPM
MAIT T-cell: 14 nTPM
NK-cell: 11 nTPM
naive CD8 T-cell: 8.9 nTPM
total PBMC: 6.9 nTPM

Brain region

thalamus: 21 nTPM
medulla oblongata: 21 nTPM
white matter: 20 nTPM
midbrain: 20 nTPM
cerebellum: 19 nTPM
spinal cord: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FUT11.

Disease | ImmuneIEDB

Conditions an epitope on FUT11 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT11 as an antibody target. Whether an autoantibody or antibody against FUT11 could matter depends on whether native FUT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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