Seroatlas · Human Serome Atlas

FUT4

Alpha-(1,3)-fucosyltransferase 4

Also known as: CD15, ELFT, FCT3A, FUC-TIV, FUT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22083
Gene: FUT4
Ensembl: ENSG00000196371
Chromosome: 11
Canonical length: 530 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>P22083|FUT4
     1  MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW ASWPAHLALA
    61  ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL QHESRCRSST PADAWRAEAA
   121  LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP WTVCVLAAAG LTCTALITYA CWGQLPPLPW
   181  ASPTPSRPVG VLLWWEPFGG RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR
   241  DLVKGPPDWP PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP
   301  SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL SRKQGLVAWV
   361  VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL LHTVARYKFY LAFENSQHLD
   421  YITEKLWRNA LLAGAVPVVL GPDRANYERF VPRGAFIHVD DFPSASSLAS YLLFLDRNPA
   481  VYRRYFHWRR SYAVHITSFW DEPWCRVCQA VQRAGDRPKS IRNLASWFER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 97 nTPM
duodenum: 12 nTPM
small intestine: 10 nTPM
stomach: 10 nTPM
colon: 8.7 nTPM
rectum: 8.3 nTPM

Single-cell type

adipocytes: 0.8 nCPM
melanocytes: 0.2 nCPM
monocyte progenitors: 0.2 nCPM
pericytes: 0.2 nCPM
corticotrophs: 0.1 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM

Immune cell

non-classical monocyte: 1.2 nTPM
classical monocyte: 0.8 nTPM
eosinophil: 0.6 nTPM
basophil: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
T-reg: 0.5 nTPM

Brain region

white matter: 7 nTPM
spinal cord: 6.3 nTPM
cerebral cortex: 6.1 nTPM
thalamus: 5.9 nTPM
medulla oblongata: 5.8 nTPM
basal ganglia: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT4 as an antibody target. Whether an autoantibody or antibody against FUT4 could matter depends on whether native FUT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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