Seroatlas · Human Serome Atlas

FUT5

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5

Also known as: FUC-TV, FUT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q11128
Gene: FUT5
Ensembl: ENSG00000130383
Chromosome: 19
Canonical length: 374 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in ceramide metabolic process; oligosaccharide metabolic process; and protein glycosylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q11128|FUT5
     1  MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM AVEPVTGAPN
    61  GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG AADCNITADS SVYPQADAVI
   121  VHHWDIMYNP SANLPPPTRP QGQRWIWFSM ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT
   181  PYGWLEPWSG QPAHPPLNLS AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK
   241  PLPKGTMMET LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP
   301  DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFHWRETLR PRSFSWALAF CKACWKLQQE
   361  SRYQTVRSIA AWFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.5 nTPM
testis: 0.4 nTPM
liver: 0.1 nTPM
salivary gland: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

oocytes: 4.6 nCPM
differentiating spermatogonia: 0.9 nCPM
early spermatids: 0.7 nCPM
early primary spermatocytes: 0.6 nCPM
late primary spermatocytes: 0.6 nCPM
late spermatids: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.5 nTPM
cerebral cortex: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.6
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT5 as an antibody target. Whether an autoantibody or antibody against FUT5 could matter depends on whether native FUT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...