FUT3

Protein identityUniProt · HPA

UniProt accession

P21217

Gene

FUT3

Ensembl

ENSG00000171124

Chromosome

19

Canonical length

361 aa

Protein class

Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>P21217|FUT3
     1  MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG SSRQDTTPTR
    61  PTLLILLRTW PFHIPVALSR CSEMVPGTAD CHITADRKVY PQADMVIVHH WDIMSNPKSR
   121  LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA
   181  HPPLNLSAKT ELVAWAVSNW KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR
   241  YKFYLAFENS LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK
   301  DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY QTVRSIAAWF
   361  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

151 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.95

gnomAD pLI

0

gnomAD missense Z

-0.26

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell recognition
• ceramide metabolic process
• oligosaccharide biosynthetic process
• oligosaccharide metabolic process
• positive regulation of cell-cell adhesion
• protein N-linked glycosylation
• protein O-linked glycosylation
• regulation of cell migration
• regulation of cell population proliferation
• carbohydrate derivative biosynthetic process
• Lewis a epitope biosynthetic process

Molecular functions

• 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
• 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
• alpha-(1->3)-fucosyltransferase activity
• fucosyltransferase activity

Cellular components

• extracellular exosome
• Golgi cisterna membrane
• Golgi membrane
• membrane

Protein domainsUniProt · Pfam · InterPro

• Glycosyl transferase family 10
• Fucosyltransferase, N-terminal
• GT10-like, C-terminal domain superfamily
• Fucosyltransferase, C-terminal
• Glycosyltransferase family 10 (fucosyltransferase) C-term
• Fucosyltransferase, N-terminal

KeywordsUniProt

• Blood group antigen
• Glycoprotein
• Glycosyltransferase
• Golgi apparatus
• Lipid metabolism
• Membrane
• Signal-anchor
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of FUT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FAM3B