Seroatlas · Human Serome Atlas

FUT9

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

Also known as: Fuc-TIX, FUT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y231
Gene
FUT9
Ensembl
ENSG00000172461
Chromosome
6
Canonical length
359 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Microtubules,Cytokinetic bridge,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9Y231|FUT9
     1  MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM KNFFSTKTDY
    61  FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY NKSHAVLIHH RDISWDLTNL
   121  PQQARPPFQK WIWMNLESPT HTPQKSGIEH LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF
   181  EVPSKEKLVC WVVSNWNPEH ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF
   241  YLSFENSIHK DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK
   301  YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV GNLEKWFWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 22 nTPM
  • cerebral cortex: 16 nTPM
  • cerebellum: 15 nTPM
  • basal ganglia: 7.1 nTPM
  • amygdala: 6.4 nTPM
  • midbrain: 6.1 nTPM

Single-cell type

  • mucous neck cells: 1,470 nCPM
  • astrocytes: 1,172 nCPM
  • bergmann glia: 649 nCPM
  • gastric chief cells: 597 nCPM
  • ependymal cells: 566 nCPM
  • brain inhibitory neurons: 426 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 65 nTPM
  • thalamus: 57 nTPM
  • cerebellum: 53 nTPM
  • hypothalamus: 52 nTPM
  • cerebral cortex: 49 nTPM
  • amygdala: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.08
gnomAD missense Z
2.02
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT9 as an antibody target. Whether an autoantibody or antibody against FUT9 could matter depends on whether native FUT9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUT9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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