SNase-like, OB-fold superfamily
IPR035437
Definition
This superfamily is composed of the Staphylococcal nuclease (SNase-like), OB-fold domain. Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are also in eukaryotes. Staphylococcal nuclease has a multi-domain organisation PMID:9003410. The human cellular coactivator p100 contains four repeats, each of which is a SNase homologue. These repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function PMID:9041650. A variety of proteins including many that are still uncharacterised belong to this group. SNase domains have an OB-fold consisting of a closed or partly open β-barrel with Greek key topology PMID:8475069.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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