Seroatlas · Human Serome Atlas

STK31

Serine/threonine-protein kinase 31

Also known as: SgK396, STK31_HUMAN, TDRD8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXU1
Gene: STK31
Ensembl: ENSG00000196335
Chromosome: 7
Canonical length: 1019 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1019 residues, UniProt reviewed canonical sequence.

>Q9BXU1|STK31
     1  MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ SINRNKDIMK
    61  IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV LKIISVEKCL VRYIDYGNTE
   121  ILNRSDIVEI PLELQFSSVA KKYKLWGLHI PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK
   181  ATSEDGTVIA QAEYGSVDIG EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI
   241  PLWGHRSNQS TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
   301  KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN HLEYTLKTYI
   361  DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG CFTTPASLNG LEIIWAEYSL
   421  AQENIKTCEY VSEGNILIAQ RNEMQQKLYM SVEDFILEVD ESSLNKRLKT LQDLSVSLEA
   481  VYGQAKEGAN SDEILKKFYD WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG
   541  SLISEDAMDN IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
   601  TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK SNLEESDDPD
   661  GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF PELPLLHPEI GLLKYMNSGG
   721  LLTMSLERDL LDAEPMKELS SKRPLVRSEV NGQIILLKGY SVDVDTEAKV IERAATYHRA
   781  WREAEGDSGL LPLIFLFLCK SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ
   841  GLHTLHKADI IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
   901  MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL LCSLICYRSS
   961  MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT ENLDKCMEKT RNGEANFDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

testis: 60 nTPM
cerebellum: 1.3 nTPM
basal ganglia: 1 nTPM
ovary: 0.6 nTPM
spinal cord: 0.5 nTPM
hippocampal formation: 0.4 nTPM

Single-cell type

late primary spermatocytes: 307 nCPM
undifferentiated spermatogonia: 183 nCPM
early primary spermatocytes: 130 nCPM
oocytes: 106 nCPM
retinal pigment epithelial cells: 55 nCPM
differentiating spermatogonia: 36 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.3 nTPM
white matter: 1.5 nTPM
pons: 1.4 nTPM
medulla oblongata: 1.3 nTPM
basal ganglia: 1 nTPM
midbrain: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.01
gnomAD missense Z: 0.26
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

acrosomal vesicle

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Tudor domain
Protein kinase-like domain superfamily
SNase-like, OB-fold superfamily
Protein kinase domain
Tudor domain
Tudor domain-containing protein 8, Tudor domain
Serine/threonine kinase-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK31 as an antibody target. Whether an autoantibody or antibody against STK31 could matter depends on whether native STK31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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