Seroatlas · Human Serome Atlas

TDRD5

Tudor domain-containing protein 5

Also known as: FLJ34823, TDRD5_HUMAN, TUDOR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAT2
Gene: TDRD5
Ensembl: ENSG00000162782
Chromosome: 1
Canonical length: 981 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in P granule organization; spermatid development; and transposable element silencing by piRNA-mediated DNA methylation. Predicted to be located in chromatoid body and pi-body. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

981 residues, UniProt reviewed canonical sequence.

>Q8NAT2|TDRD5
     1  MSEQERIQEC LRKEIRSLLI STKDGLSPQE LEKEYLLMVG NHLPLRILGY RSTMELVLDM
    61  PDVVRVCPGA GGTVILKAIP DESTKGIASL VAKQRSSHKL RNSMHKGRPS IYSGPRSHRR
   121  VPYRGRVAPI LPAVVKSELK DLLALSPVLL SDFEKAFAKR FGRSFQYMQY GFLSMFEVLN
   181  AASDVISVEQ TRAGSLLMLK KSVTEEKPRG CPAGKIFTQP FRMKQGSYST GFPVAKPCFS
   241  QPTSNMEPPK QIMSMEKTSK LNVVETSRLN HTEKLNQLEN TFKSVIAQIG PGGTISSELK
   301  HKIKFVVSKF PEGLFISKLL GEYEVIFKEQ LSPKKLGFLN VTELVGALSD ILHVEFRKGH
   361  QDLLVFDADK KPLPPVQSDK KIEAKACVSS PPRNSLSTAA VKETVWNCPS KKQKEPQQKI
   421  CKKPNLVVKP LQLQVETNKS ELNLAMANHD IPPDAVPNKK LCRLPPLDTS SLIGVFVEYI
   481  ISPSQFYIRI YSRDSSELLE DMMIEMRRCY SNQLVSDRYV MPECFIQPGH LCCVRISEDK
   541  WWYRVIIHRV LEKQEVEVFY PDFGNIGIVQ KSSLRFLKCC YTKLPAQAIP CSLAWVRPVE
   601  EHWTSKAILQ FQKLCGLKPL VGVVDEYVDG ILNIFLCDTS SNEDVYFHHV LRTEGHAIVC
   661  RENISSKGFS ELNPLALYTT SSGGPEDIVL TELGYPSQQH YFNEDRKISP QSKESELRIL
   721  DEIPTGMPCL ESVTIGDDIW DENWLPLQAK MGKGGDAASH LFTASLGGKN QYSSCKEMPQ
   781  KDWCFSTPKD TWDDSWQPSG LVNGTKVEVH KPEVLGAQEK NTGTNRTQKQ LDINGSSDSS
   841  TLPKLEEFCT SLTQSEQSAD GSQSEPNNSQ TQPKQIQLST AAPCSTTAVD DSAEKPSGSV
   901  ESSPEILKNE DFSSSRAITL YKDKRQESVD QLSLILSYEC QISQKLYIPR STATAALGAA
   961  ARLATSRSLL HWYPSVKRME A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
epididymis: 6.2 nTPM
breast: 3.3 nTPM
basal ganglia: 2.4 nTPM
pituitary gland: 2.3 nTPM
kidney: 1.5 nTPM

Single-cell type

early spermatids: 72 nCPM
podocytes: 70 nCPM
early primary spermatocytes: 45 nCPM
late primary spermatocytes: 42 nCPM
retinal pigment epithelial cells: 30 nCPM
undifferentiated spermatogonia: 27 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 3.5 nTPM
hypothalamus: 2.8 nTPM
pons: 2.6 nTPM
midbrain: 2.5 nTPM
cerebral cortex: 2.1 nTPM
amygdala: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRD5 as an antibody target. Whether an autoantibody or antibody against TDRD5 could matter depends on whether native TDRD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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