Seroatlas · Human Serome Atlas

TDRD15

Tudor domain-containing protein 15

Also known as: TDR15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B5MCY1
Gene
TDRD15
Ensembl
ENSG00000218819
Chromosome
2
Canonical length
1934 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TDRD15 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1934 residues, UniProt reviewed canonical sequence.

>B5MCY1|TDRD15
     1  MDSTSFLPTF LDVDLTISHI KCLPKDILVK FQGIKSNECE FDYHVLQREI QHTPKVKNNV
    61  EIDEFCLVEE RVSGEWQRGR VMEKKNELYT VLLIDRGEEL RVAGPQIASA CGNLFELPPR
   121  VVFGIFANIL PVGEKWSPKA LNYFKSLVGI QVKGYVQAIL PLQMFLFEVP KIISQALELQ
   181  LGRLVDGDSF RLIVEMLEEF PQQMPDLLQH KRPELSLGNK DTSLDIQHVL DKLQPSLSVG
   241  STESVKVSSA LSPSKFYCQL IKWTPELENL TAHMTLHYDT VCQETSPTCD NFGLLCVARR
   301  RNGQWHRGIL QQLLPPNQVK IWFMDYGSSE AIPSIYVKKL KQDFILVPLF SFPCSLTCLH
   361  SPDRDARIFQ LSIFKQALLG QVVYAHIDWF NKDECLYYVT LQTQESTVNS KCLLKTVGTQ
   421  VLCPMSDSKI SNILSETSVS DVNSFAVESF MGNIEWSIDS LNKKGILKVG FPIKTVQMEI
   481  EAAYIAFIAY VLNPSNFWVR TNDHRNEFQE IMKNINKFYD LCENDEMILR KPEPGLFCCA
   541  RYSKDRRFYR AVITEINGYK INVYFLDYGN TDSIPFFDVK ILLPEFCELP ALAMCCSLAH
   601  IFPVEDLWTK AAIDYFKKLV LNKAILLQVI AKKDDKYTVN IQSVEASENI DVISLMLQAG
   661  YAEYFQVELE YFPKSVSEYS MLNSESKNKV NIKKVISALL EGPKSKKYHS NNLVENNLSL
   721  PKSLAVNISE FKNPFTLSVG PESSWPYKEY IFRPGTVLEV KCSCYYGPGD FSCQLQCKSE
   781  DLKLLMEQIQ NYYSIHSDPY EIGQTACVAK YSGKWCRAAV LTQVSKEVDI VFVDYGYQKR
   841  VLIEDLCAIN PRFLLLESQA FRCCLNHFIE PVSCKLFSWT RKAFRDLWNF ISSSRGLLTC
   901  IIYALVIIHP NHLYNLVDLQ SSFTSAKEFL MNRGSAQYIT LSETFPSLFS LYSYCYSSFN
   961  IQIGSEEEVY ISHIYSPQKF YCQLGRNNKD LEMIETKITE SVNLQNFPKY DSNKMRVCIS
  1021  KYVEDGLSYR ALAIPTDSSS EFQVYFVDFG NKQLVGENML RAISAQFPEL LFTPMQAIKC
  1081  FLSDLRDVDI PAEISSWFKD NFLGRSLKAI ILSQESDGQL GIELYDGSQY INEKIKVLLH
  1141  AYGKRHCDQA CCMEKSNKIN ENKRFTTSLK GKTGNNYRHN VINKPSPVTY SERKIDQLMH
  1201  PKNIHARFLK PSVCYKMEPV SKNKMKTSLN DGLKGIKIVP GAAHILENRR VGQKSVKVVS
  1261  QSFIRALNQT TSQNPYDLIR PQIKDLPQPQ IYLNAKVKGY VSNISNPANF HIQLAENESV
  1321  IIRLADALNA TARRLRERKS VKPLVGDLVV AEYSGDNAIY RAVIKKILPG NSFEVEFIDY
  1381  GNSAIVNTSK IYELQREFLT VPQLGIHAFL SGVKWNEPDE IWDDKTVDYF TSKVHNKTVY
  1441  CEFLKKHDQK WEVNMICDEK CVINELLKWK ACSKLQKSAL QMPQVLSQKV RPGDNEMKKG
  1501  KSNESEGSMN SNQQLFKIPL EEFKLGQLEK AEMLNVSKSG RFYVKLSKNK KILSDLIVLI
  1561  TKEEKKSPFL SMESIEKGLE CLAKSKNTLK WHRSKVEEKY VDDKVLVFLV DCGIYEIVPV
  1621  CNTKLLSNEI RNIPRQAVPC KWIWFENSKN ISFECLFADL EINILFLKYL DAVWEVEILV
  1681  DDLLLLEYLN LNTVPVEENK LRLAEIVYNI ESKTPVSSCT IKSFTWVQFQ NDRQYSGIAT
  1741  AVSDPSDFSI QLEDFFDIMK YLFMLLSDLP ETLQTLPQEF IIPGSSCLFK YKSEDQWNRV
  1801  EISEVSPQSL CLVLVDYGFS FYIRYSEIIN LKVVPEELLN LPRLSYPCIL YGILPAKGKH
  1861  WSEEAKIFFR DFLSKPDLVF QFREYHSETK LKVDVIHEKN NLADILVASG LATYSKDSPH
  1921  LDAITATESA KNPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRD15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
5.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.1 nTPM
  • liver: 0.9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early primary spermatocytes: 40 nCPM
  • late primary spermatocytes: 38 nCPM
  • late spermatids: 23 nCPM
  • gonadotrophs: 11 nCPM
  • differentiating spermatogonia: 7.6 nCPM
  • early spermatids: 6.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • pons: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0
gnomAD missense Z
2.07

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRD15 as an antibody target. Whether an autoantibody or antibody against TDRD15 could matter depends on whether native TDRD15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRD15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRD15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TDRD15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...