Seroatlas · Human Serome Atlas

TDRD1

Tudor domain-containing protein 1

Also known as: CT41.1, TDRD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXT4
Gene: TDRD1
Ensembl: ENSG00000095627
Chromosome: 10
Canonical length: 1180 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]

Canonical amino-acid sequenceUniProt

1180 residues, UniProt reviewed canonical sequence.

>Q9BXT4|TDRD1
     1  MSVKSPFNVM SRNNLEAPPC KMTEPFNFEK NENKLPPHES LRSPGTLPNH PNFRLKSSEN
    61  GNKKNNFLLC EQTKQYLASQ EDNSVSSNPN GINGEVVGSK GDRKKLPAGN SVSPPSAESN
   121  SPPKEVNIKP GNNVRPAKSK KLNKLVENSL SISNPGLFTS LGPPLRSTTC HRCGLFGSLR
   181  CSQCKQTYYC STACQRRDWS AHSIVCRPVQ PNFHKLENKS SIETKDVEVN NKSDCPLGVT
   241  KEIAIWAERI MFSDLRSLQL KKTMEIKGTV TEFKHPGDFY VQLYSSEVLE YMNQLSASLK
   301  ETYANVHEKD YIPVKGEVCI AKYTVDQTWN RAIIQNVDVQ QKKAHVLYID YGNEEIIPLN
   361  RIYHLNRNID LFPPCAIKCF VANVIPAEGN WSSDCIKATK PLLMEQYCSI KIVDILEEEV
   421  VTFAVEVELP NSGKLLDHVL IEMGYGLKPS GQDSKKENAD QSDPEDVGKM TTENNIVVDK
   481  SDLIPKVLTL NVGDEFCGVV AHIQTPEDFF CQQLQSGRKL AELQASLSKY CDQLPPRSDF
   541  YPAIGDICCA QFSEDDQWYR ASVLAYASEE SVLVGYVDYG NFEILSLMRL CPIIPKLLEL
   601  PMQAIKCVLA GVKPSLGIWT PEAICLMKKL VQNKIITVKV VDKLENSSLV ELIDKSETPH
   661  VSVSKVLLDA GFAVGEQSMV TDKPSDVKET SVPLGVEGKV NPLEWTWVEL GVDQTVDVVV
   721  CVIYSPGEFY CHVLKEDALK KLNDLNKSLA EHCQQKLPNG FKAEIGQPCC AFFAGDGSWY
   781  RALVKEILPN GHVKVHFVDY GNIEEVTADE LRMISSTFLN LPFQGIRCQL ADIQSRNKHW
   841  SEEAITRFQM CVAGIKLQAR VVEVTENGIG VELTDLSTCY PRIISDVLID EHLVLKSASP
   901  HKDLPNDRLV NKHELQVHVQ GLQATSSAEQ WKTIELPVDK TIQANVLEII SPNLFYALPK
   961  GMPENQEKLC MLTAELLEYC NAPKSRPPYR PRIGDACCAK YTSDDFWYRA VVLGTSDTDV
  1021  EVLYADYGNI ETLPLCRVQP ITSSHLALPF QIIRCSLEGL MELNGSSSQL IIMLLKNFML
  1081  NQNVMLSVKG ITKNVHTVSV EKCSENGTVD VADKLVTFGL AKNITPQRQS ALNTEKMYRM
  1141  NCCCTELQKQ VEKHEHILLF LLNNSTNQNK FIEMKKLLKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
kidney: 1.5 nTPM
ovary: 1.2 nTPM
heart muscle: 0.5 nTPM
prostate: 0.5 nTPM
spleen: 0.5 nTPM

Single-cell type

oocytes: 97 nCPM
undifferentiated spermatogonia: 54 nCPM
differentiating spermatogonia: 38 nCPM
late primary spermatocytes: 30 nCPM
early primary spermatocytes: 29 nCPM
early spermatids: 12 nCPM

Immune cell

plasmacytoid DC: 1.6 nTPM
basophil: 0.6 nTPM
neutrophil: 0.6 nTPM
NK-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM

Brain region

white matter: 3.6 nTPM
cerebral cortex: 3.4 nTPM
cerebellum: 3.2 nTPM
pons: 3.1 nTPM
thalamus: 3.1 nTPM
midbrain: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TDRD1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 143 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.4
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, MYND-type
Tudor domain
SNase-like, OB-fold superfamily
Tudor domain-containing
Tudor domain
MYND finger
Tudor domain-containing protein 1, first Tudor domain
Tudor domain-containing protein 1, second Tudor domain
Tudor domain-containing protein 1, third Tudor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TDRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRD1 as an antibody target. Whether an autoantibody or antibody against TDRD1 could matter depends on whether native TDRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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