Seroatlas · Human Serome Atlas

CDH9

Cadherin-9

Also known as: CADH9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULB4
Gene: CDH9
Ensembl: ENSG00000113100
Chromosome: 5
Canonical length: 789 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

789 residues, UniProt reviewed canonical sequence.

>Q9ULB4|CDH9
     1  MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF
    61  FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE
   121  KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ
   181  VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD
   241  MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN
   301  AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH
   361  LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS
   421  VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD
   481  INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV
   541  DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC
   601  TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN
   661  DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL
   721  KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM
   781  YGGDDSDRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.5 nTPM
kidney: 5.4 nTPM
basal ganglia: 2.6 nTPM
testis: 2 nTPM
bone marrow: 1.8 nTPM
amygdala: 1.1 nTPM

Single-cell type

proximal tubule cells: 357 nCPM
brain inhibitory neurons: 343 nCPM
brain excitatory neurons: 278 nCPM
other brain neurons: 206 nCPM
retinal bipolar cells: 49 nCPM
distal convoluted tubule cells: 12 nCPM

Immune cell

neutrophil: 5 nTPM
memory B-cell: 2.6 nTPM
naive B-cell: 2.1 nTPM
basophil: 1.2 nTPM
non-classical monocyte: 0.7 nTPM
T-reg: 0.7 nTPM

Brain region

cerebral cortex: 41 nTPM
amygdala: 39 nTPM
basal ganglia: 32 nTPM
hippocampal formation: 31 nTPM
white matter: 29 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.83
gnomAD missense Z: 1.76
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH9 as an antibody target. Whether an autoantibody or antibody against CDH9 could matter depends on whether native CDH9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH9 is annotated at the cell surface, where native CDH9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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